Contribution of the central nervous system to peripheral neural control in obesity and diabetes.

中枢神经系统对肥胖和糖尿病周围神经控制的贡献。

• 批准号: nhmrc : 445314
• 负责人: Prof Emilio Badoer
• 金额: $ 30.32万
• 依托单位: Royal Melbourne Institute of Technology
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/contribution-central-nervous-obesity-diabetes/97361
• 关键词: Contribution; central; nervous; system; peripheral

Obesity and diabetes are becoming major worldwide public health problems. A characteristic of human obese diabetes is a marked increase in sympathetic nerve activity to the kidneys and to the muscle. The cause of this overactivity is unknown, but undoubtedly involves the central nervous system. Within the brain are a select group of regions that are able to directly influence the activation of the sympathetic nervous system. We suspect these areas to play a critical role in the overactivity of the sympathetic nerve activity in obese diabetics. Indeed, we believe that there are specific chemical messengers in these select brain areas that are normally finely balanced. In obesity - diabetes, this balance is disturbed. Finally, we hypothesise that exercise, which is known to have beneficial effects for obesity - diabetes, restores the balance of the neurochemicals and this contributes to the positive outcomes of exercise.

肥胖和糖尿病正成为世界范围内的主要公共卫生问题。人类肥胖糖尿病的一个特征是肾脏和肌肉的交感神经活动显着增加。这种过度活动的原因尚不清楚，但无疑与中枢神经系统有关。大脑中有一组精选的区域，能够直接影响交感神经系统的激活。我们怀疑这些区域在肥胖糖尿病患者交感神经活动过度的过程中起着关键作用。事实上，我们认为，在这些精选的大脑区域中，存在着特定的化学信使，这些区域通常处于微妙的平衡状态。在肥胖-糖尿病患者中，这种平衡被打破。最后，我们假设，众所周知，运动对肥胖-糖尿病有好处，它恢复了神经化学物质的平衡，这有助于运动的积极结果。