The paraventricular nucleus in heart failure

心力衰竭中的室旁核

• 批准号: nhmrc : 124422
• 负责人: Prof Emilio Badoer
• 金额: $ 26.48万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/paraventricular-nucleus-heart-failure/95672
• 关键词: paraventricular; nucleus; heart; failure

Heart failure is a severely debilitating condition with a poor prognosis. It is characterized by retention of fluid and high nervous activity especially to the kidneys and the heart. Even with the best current treatment available, patients with heart failure still suffer from abnormally high nerve activity to the further detriment of this condition. The successful completion of this project will provide considerable insight into the role of the brain in the elevated nerve activity in heart failure. It will also provide us with a significant understanding of the role in reflex sympathetic nerve regulation of an important brain region known as the hypothalamic paraventricular nucleus (PVN). Our findings will help us understand the nature of the neurotransmitters contributing to the reflex nerve regulation and the specific neurons within the PVN involved. This knowledge could help us to identify novel potential therapeutic targets within the brain to alleviate the problems observed in heart failure.

心力衰竭是一种严重衰弱的疾病，预后不良。它的特点是液体潴留和高神经活动，特别是肾脏和心脏。即使采用目前最好的治疗方法，心力衰竭患者仍然会遭受异常高的神经活动，进一步损害这种情况。该项目的成功完成将为心力衰竭中大脑在神经活动升高中的作用提供相当多的见解。这也将为我们提供一个重要的了解反射交感神经调节的作用，一个重要的大脑区域称为下丘脑室旁核（PVN）。我们的研究结果将有助于我们了解神经递质的性质，有助于反射神经调节和PVN内的特定神经元参与。这些知识可以帮助我们确定大脑中新的潜在治疗靶点，以减轻心力衰竭中观察到的问题。