CCU-MRU, A MULTIDISCIPLINARY MYCOLOGY RESEARCH UNIT

CCU-MRU，多学科真菌学研究单位

• 批准号: 3091474
• 负责人: ROBERT IRVING LEHRER
• 金额: $ 36.12万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-09-01 至 1989-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3091474
• 关键词: host organism interaction; microorganism disease chemotherapy; mycosis; virulence

We are performing a multidisciplinary investigation of basic and clinical aspects of fungal infection. Our project includes investigations to evaluate: molecular aspects of growth and morphogenesis in Mucorales and Candida albicans; mycotoxin production and susceptibility by pathogenic fungi, including the use of this phenomenon for biotyping fungal isolates; the prevalence and significance of fungal virus infection; new immunodiagnostic methods for the mycoses; and the contribution of phagocytic cells to host resistance to fungal infections.

我们正在进行基础和临床的多学科研究

项目成果

Inhibition of growth of Histoplasma capsulatum by lymphokine-stimulated macrophages.

淋巴因子刺激的巨噬细胞抑制荚膜组织胞浆菌的生长。

• 发表时间: 1984
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Wu-Hsieh,B;Howard,DH
• 通讯作者: Howard,DH

Characterization of two crystal forms of neutrophil cationic protein NP2, a naturally occurring broad-spectrum antimicrobial agent from leukocytes.

中性粒细胞阳离子蛋白 NP2 的两种晶型的表征，NP2 是一种来自白细胞的天然广谱抗菌剂。

• DOI: 10.1016/0022-2836(84)90252-3
• 发表时间: 1984
• 期刊: Journal of molecular biology
• 影响因子: 5.6
• 作者: Westbrook,EM;Lehrer,RI;Selsted,ME
• 通讯作者: Selsted,ME

Three genes for the elongation factor EF-1 alpha in Mucor racemosus.

总状毛霉中延伸因子 EF-1 α 的三个基因。

• DOI: 10.1128/mcb.6.2.593-600.1986
• 发表时间: 1986
• 期刊: Molecular and cellular biology
• 影响因子: 5.3
• 作者: Linz,JE;Katayama,C;Sypherd,PS
• 通讯作者: Sypherd,PS

Newborn rabbit alveolar macrophages are deficient in two microbicidal cationic peptides, MCP-1 and MCP-2.

新生兔肺泡巨噬细胞缺乏两种杀菌阳离子肽 MCP-1 和 MCP-2。

• DOI: 10.1164/arrd.1985.132.4.901
• 发表时间: 1985
• 期刊: The American review of respiratory disease
• 作者: Ganz,T;Sherman,MP;Selsted,ME;Lehrer,RI
• 通讯作者: Lehrer,RI

Regulation of protein synthesis factor EF-1 alpha in Mucor racemosus.

总状毛霉中蛋白质合成因子 EF-1 α 的调节。

• DOI: 10.1128/mcb.5.5.1100-1103.1985
• 发表时间: 1985
• 期刊: Molecular and cellular biology
• 影响因子: 5.3
• 作者: Fonzi,WA;Katayama,C;Leathers,T;Sypherd,PS
• 通讯作者: Sypherd,PS