Control of corticalisation by SOCS3 in osteocytes

SOCS3 控制骨细胞中的皮质化

• 批准号: nhmrc : 1120978
• 负责人: A/Pr Natalie Sims
• 金额: $ 61.46万
• 依托单位: St. Vincent's Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/control-corticalisation-socs3-osteocytes/946657
• 关键词: Control; corticalisation; SOCS3; osteocytes

Treating and preventing painful fractures could be improved by strengthening cortical bone – the hard outer shell of all bones in the skeleton. We don’t know how cortical bone forms, but if we did, we could improve its strength. We have found that a brain-like network of cells inside the skeleton, called osteocytes, use a specific signal, called SOCS3, to make strong cortical bone. This study will find out how SOCS3 works and find new ways to make cortical bone strong and healthy.

治疗和预防疼痛性骨折可以通过强化皮质骨（骨骼中所有骨骼的坚硬外壳）来改善。我们不知道皮质骨是如何形成的，但如果我们知道，我们就能提高它的强度。我们已经发现，骨骼内部的一个类似大脑的细胞网络，称为骨细胞，使用一种称为SOCS3的特定信号来制造坚固的皮质骨。这项研究将找出SOCS3是如何工作的，并找到使皮质骨强壮和健康的新方法。