PAPILLOMAVIRUS ANIMAL MODEL FOR THERAPY EVALUATION

用于治疗评估的乳头状病毒动物模型

• 批准号: 3597185
• 负责人: ANTHONY J FARAS
• 金额: $ 21.21万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-03-01 至 1993-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3597185
• 关键词: Papillomavirus; Shope papilloma; antiviral agents; athymic mouse; cervix neoplasms; condyloma acuminatum; disease /disorder model; immunodeficiency; immunosuppression; laboratory rabbit; rabbit papillomavirus; sexually transmitted diseases; virus cytopathogenic effect; virus infection mechanism

Papillomavirus infections are responsible for several clinically important diseases. The annual worldwide incidence of cervical carcinoma is about 450,000 cases and prior infection with a human papillomavirus (HPV) has been strongly implicated as the most consistently identified cofactor in the etiology of the neoplasm. In addition, HPV is the causative agent of condyloma acuminatum, a sexually transmitted infection which is currently spreading more rapidly than genital herpes. The incidence of this disease increased 500% between 1966 and 1981 (MMWR 32:306- 308, 1983). Exuberant growths of condyloma are often seen in immunosuppressed patients; those whose immune systems are suppressed by temporary conditions such as pregnancy as well as AIDS patients and other seriously immune deficient individuals. HPV is also the cause of recurrent respiratory papillomatosis (RRP), a rare (approximately 1500 new cases per year in the U.S.) but devastating infection which afflicts children as well as adults. In addition to supporting clinical trials of promising therapeutic agents, the Antiviral Substances Program (ASP) maintains a variety of animal models of human infections in which experimental therapies can be evaluated prior to clinical trial. Several animal models of papillomavirus infections are available which share many features with human disease. The objectives of this contract are: 1. The use of the Shope papillomavirus rabbit model and the xenograft model of human papillomavirus infection of nude mice for evaluation of experimental antiviral therapies. 2. Basic research on the natural history and pathogenesis of papillomavirus infections that may well suggest successful strategies for controlling infection.

乳头瘤病毒感染导致多种临床症状 重要疾病。 全球每年宫颈癌发病率 癌症大约有 450,000 例并且之前曾被人类感染过 乳头瘤病毒 (HPV) 被强烈认为是最常见的 一致地鉴定了肿瘤病因学中的辅助因子。 此外，HPV是尖锐湿疣的病原体 acuminatum，一种性传播感染，目前 传播速度比生殖器疱疹快。 这种情况的发生 1966 年至 1981 年间，疾病增加了 500% (MMWR 32:306- 308, 1983）。 尖锐湿疣生长旺盛常见于 免疫抑制患者；那些免疫系统处于 受到怀孕等暂时情况的抑制 艾滋病患者和其他严重免疫缺陷的人。 HPV 也是复发性呼吸道乳头状瘤病的原因 (RRP)，罕见（美国每年大约有 1500 个新病例） 但这是一种毁灭性的感染，对儿童和成人都有影响。 除了支持有前景的治疗方法的临床试验 剂，抗病毒物质计划（ASP）维护 多种人类感染动物模型，其中 实验疗法可以在临床试验之前进行评估。 已有多种乳头瘤病毒感染动物模型 它们与人类疾病有许多共同特征。 的目标 该合同是： 1. Shope乳头瘤病毒兔模型的使用及 人乳头瘤病毒感染裸鼠异种移植模型 用于评估实验性抗病毒疗法。 2. 自然史和发病机制的基础研究 乳头瘤病毒感染很可能表明成功 控制感染的策略。