PAPILLOMAVIRUS ANIMAL MODEL FOR THERAPY EVALUATION

乳头瘤病毒感染是临床上几种疾病的原因 重要的疾病。世界范围内宫颈癌的年发病率 癌症大约有45万例，以前感染过人类 乳头瘤病毒(HPV)被强烈认为是 在肿瘤的病因学中一直被确认为辅因子。 此外，人乳头瘤病毒也是尖锐湿疣的致病因素。 尖锐湿疣，一种性传播感染，目前 传播速度比生殖器疱疹更快。这种情况的发生率 疾病在1966至1981年间增长了500%(MMWR 32：306- 308,1983)。尖锐湿疣的旺盛生长常见于 免疫抑制的患者；那些免疫系统 因怀孕等临时性疾病而受到抑制 艾滋病患者和其他严重免疫缺陷的个人。 HPV也是呼吸道乳头状瘤病复发的原因。 (RRP)，一种罕见的(美国每年约有1500例新病例) 但儿童和成人都会受到毁灭性的感染。 除了支持前景看好的治疗药物的临床试验 药物，抗病毒物质计划(ASP)保持 多种人类感染的动物模型 试验性疗法可以在临床试验之前进行评估。 有几种乳头瘤病毒感染的动物模型可用 这与人类疾病有许多相似之处。的目标 这份合同是： 1.Shope乳头瘤病毒兔模型的应用 人乳头瘤病毒裸鼠移植瘤模型的建立 用于评估实验性的抗病毒疗法。 2.黄褐斑的自然历史和发病机制的基础研究 乳头瘤病毒感染很可能预示着成功 控制感染的策略。

Papillomavirus infections are responsible for several clinically important diseases. The annual worldwide incidence of cervical carcinoma is about 450,000 cases and prior infection with a human papillomavirus (HPV) has been strongly implicated as the most consistently identified cofactor in the etiology of the neoplasm. In addition, HPV is the causative agent of condyloma acuminatum, a sexually transmitted infection which is currently spreading more rapidly than genital herpes. The incidence of this disease increased 500% between 1966 and 1981 (MMWR 32:306- 308, 1983). Exuberant growths of condyloma are often seen in immunosuppressed patients; those whose immune systems are suppressed by temporary conditions such as pregnancy as well as AIDS patients and other seriously immune deficient individuals. HPV is also the cause of recurrent respiratory papillomatosis (RRP), a rare (approximately 1500 new cases per year in the U.S.) but devastating infection which afflicts children as well as adults. In addition to supporting clinical trials of promising therapeutic agents, the Antiviral Substances Program (ASP) maintains a variety of animal models of human infections in which experimental therapies can be evaluated prior to clinical trial. Several animal models of papillomavirus infections are available which share many features with human disease. The objectives of this contract are: 1. The use of the Shope papillomavirus rabbit model and the xenograft model of human papillomavirus infection of nude mice for evaluation of experimental antiviral therapies. 2. Basic research on the natural history and pathogenesis of papillomavirus infections that may well suggest successful strategies for controlling infection.