DEVELOPMENT OF COPOLYMER DENTAL ADHESIVE

共聚物牙科粘合剂的研制

• 批准号: 3732577
• 负责人: CECIL C CHAPPELOW
• 金额: --
• 依托单位: UNIVERSITY OF MISSOURI KANSAS CITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3732577
• 关键词: biomaterial compatibility; biomaterial development /preparation; biomaterial evaluation; biomaterial interface interaction; chemical bond; chemical structure function; chemical synthesis; composite resins; copolymer; dental adhesive /sealant; dental bonding material; dentin; infrared spectrometry; isocyanates; monomer; physical property; polymerization; polyvinyls; scanning electron microscopy; tooth enamel; tooth surface; vinyl ether

The ultimate objective of this program is the development of a superior dental adhesive that will not only produce a permanent bond to dentin, but to other tooth substrates and restorative materials such as dental composites. The specific aims of this program are: (1) To identify the optimum unsaturated isocyanate/vinyl monomer compositions and determine their reactivity ratios and Q and e values. (2) To control via reactivity ratios the composition of these proposed vinyl copolymers in terms of the content and distribution of desirable functional groups. (3) To determine the adhesive properties of the copolymers to dentin and enamel substrates and evaluate system modifiers that enhance their adhesion. (4) To ascertain the concentration of isocyanate functionality necessary in the copolymer to obtain a maximum adhesive strength to the dental substrate. (5) To ascertain the residual unsaturation, molecular weight, and molecular weight distribution required by the copolymers to provide maximum polymer strength obtainable with final cure. (6) To determine the physical and mechanical properties of the new copolymers developed on this program as potentially superior dental adhesives. (7) To determine and evaluate the microleakage and marginal gap control of these new dental adhesives. (8) To integrate the results of these studies into a fundamental understanding of adhesive molecular design for optimum performance in the oral environment. This subproject will encompass five major phases. Phase 1 will determine monomer reactivity ratios and accomplish aims 1 and 2. Phase 2 is the design and synthesis of copolymer adhesives addressed in specific aims 3, 4, and 5. For Phase 3 the methodology is proposed for the characterization of physicochemical properties and the significance of these properties is addressed in specific aims 4, 5, and 6. Phase 4 is the determination of dental properties and the further enhancement of the adhesive bond strength through system modifiers in specific aim 7. The final phase will address the specific aim 8 and be a critical assessment of the biocompatibility and performance of candidate copolymer dental adhesives, and the development of a protocol for future clinical studies.

这项计划的最终目标是发展一个更优秀的 牙科粘合剂不仅能与牙本质产生永久粘结，而且 其他牙齿基材和修复材料，如牙科 复合材料。这项计划的具体目标是： (1)确定最佳不饱和异氰酸酯/乙烯基单体 并测定它们的竞聚率以及Q和e值。 (2)通过折射率控制这些建议的组成 乙烯基共聚物中所需物质的含量和分布 功能基团。 (3)测定共聚物对牙本质和牙本质的粘附性 釉质底物和评估系统改进剂以增强其 粘附力。 (4)确定所需的异氰酸酯官能团的浓度 该共聚物可获得最大的牙科粘接强度 底物。 (5)确定剩余不饱和度、相对分子质量和相对分子质量 提供最大聚合物所需的共聚物重量分布 最终固化后可获得的强度。 (6)确定新材料的物理力学性能 在该计划中开发的具有潜在优势的牙科用共聚物 粘合剂。 (7)确定和评价微渗漏和边际间隙控制 这些新型牙科粘合剂。 (8)将这些研究的结果整合为一个基本的 对胶粘剂分子设计的理解，以获得最佳性能 口腔环境。 这一分项目将包括五个主要阶段。第一阶段将决定 单体竞聚率和完成目标1和2。阶段2是 具体目标3中涉及的共聚胶粘剂的设计和合成， 4和5。对于阶段3，提出了表征的方法 这些物理化学性质的意义是 在具体目标4、5和6中处理。阶段4是确定 牙科性能与粘接强度的进一步提高 通过特定目标中的系统修改器7.最后阶段将解决 具体目标8，并对生物相容性和 牙科用候选共聚胶粘剂的性能及发展 未来临床研究的方案。