DEVELOPMENT OF COPOLYMER DENTAL ADHESIVE

共聚物牙科粘合剂的研制

• 批准号: 5208822
• 负责人: CECIL C CHAPPELOW
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5208822
• 关键词: biomaterial compatibility; biomaterial development /preparation; biomaterial evaluation; biomaterial interface interaction; carbonates; chemical structure function; chemical synthesis; copolymer; cytotoxicity; dental adhesive /sealant; dental bonding material; dentin; free radicals; infrared spectrometry; mutagens; polymerization; polyvinyls; scanning electron microscopy; spirane; tooth enamel; tooth surface

The ultimate objective of this program is the development of a superior dental adhesive that will not only produce a permanent bond to dentin, but to other tooth substrates and restorative materials such as dental composites. The specific aims of this program are: (1) To identify the optimum unsaturated isocyanate/vinyl monomer compositions and determine their reactivity ratios and Q and e values. (2) To control via reactivity ratios the composition of these proposed vinyl copolymers in terms of the content and distribution of desirable functional groups. (3) To determine the adhesive properties of the copolymers to dentin and enamel substrates and evaluate system modifiers that enhance their adhesion. (4) To ascertain the concentration of isocyanate functionality necessary in the copolymer to obtain a maximum adhesive strength to the dental substrate. (5) To ascertain the residual unsaturation, molecular weight, and molecular weight distribution required by the copolymers to provide maximum polymer strength obtainable with final cure. (6) To determine the physical and mechanical properties of the new copolymers developed on this program as potentially superior dental adhesives. (7) To determine and evaluate the microleakage and marginal gap control of these new dental adhesives. (8) To integrate the results of these studies into a fundamental understanding of adhesive molecular design for optimum performance in the oral environment. This subproject will encompass five major phases. Phase 1 will determine monomer reactivity ratios and accomplish aims 1 and 2. Phase 2 is the design and synthesis of copolymer adhesives addressed in specific aims 3, 4, and 5. For Phase 3 the methodology is proposed for the characterization of physicochemical properties and the significance of these properties is addressed in specific aims 4, 5, and 6. Phase 4 is the determination of dental properties and the further enhancement of the adhesive bond strength through system modifiers in specific aim 7. The final phase will address the specific aim 8 and be a critical assessment of the biocompatibility and performance of candidate copolymer dental adhesives, and the development of a protocol for future clinical studies.

该计划的最终目标是培养优秀的 牙科粘合剂不仅能与牙本质产生永久的粘合，而且 其他牙齿基质和修复材料，例如牙科 复合材料。 该计划的具体目标是： (1) 确定最佳不饱和异氰酸酯/乙烯基单体 成分并确定其反应率以及 Q 和 e 值。 (2) 通过反应率来控制这些建议的组成 乙烯基共聚物的含量和分布 功能组。 (3) 测定共聚物对牙本质的粘合性能 釉质基材并评估可增强其性能的系统改性剂 附着力。 (4) 确定异氰酸酯官能团的浓度 共聚物以获得对牙齿的最大粘合强度 基材。 (5) 测定残余不饱和度、分子量和分子量 共聚物所需的重量分布以提供最大聚合物 最终固化可获得的强度。 (6)测定新材料的物理机械性能 在此项目上开发的共聚物作为潜在的优质牙科材料 粘合剂。 (7) 确定和评估微泄漏和边缘间隙控制 这些新型牙科粘合剂。 (8) 将这些研究成果整合为基础 了解粘合剂分子设计以实现最佳性能 口腔环境。 该子项目将分为五个主要阶段。 第一阶段将确定 单体反应率并实现目标 1 和 2。第 2 阶段是 针对特定目标 3 的共聚物粘合剂的设计和合成， 4 和 5。对于第 3 阶段，提出了表征方法 理化性质以及这些性质的意义是 在具体目标 4、5 和 6 中得到解决。第 4 阶段是确定 牙科性能和粘合强度的进一步增强 通过特定目标 7 中的系统修改器。最后阶段将解决 具体目标 8 并对生物相容性和 候选共聚物牙科粘合剂的性能以及开发 未来临床研究的方案。