Integrated Matrix Resin/Adhesive Systems

集成基质树脂/粘合剂系统

• 批准号: 6651292
• 负责人: CECIL C CHAPPELOW
• 金额: $ 30.66万
• 依托单位: UNIVERSITY OF MISSOURI KANSAS CITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-15 至 2003-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6651292
• 关键词: biomaterial compatibility; biomaterial development /preparation; biomaterial evaluation; chemical structure function; chemical synthesis; chromatography; composite resins; dental adhesive /sealant; dental bonding material; dental materials; infrared spectrometry; mass spectrometry; nuclear magnetic resonance spectroscopy; polymerization

DESCRIPTION (provided by applicant): The overall goal is to generate rationally designed expanding monomers and coreactants for a low stress, low shrinkage high performance resin system with optimal cure characteristics, structural integrity, and biocompatibility that has the potential of long term clinical success as a stable adhesive/matrix resin for dental composites. The successful development of these material would greatly increase the longevity of dental composite/adhesive systems and substantially improve dental patient care. In order to achieve these goals the following specific aims will be addressed: (1) To synthesize the most promising expandable monomer and polymer structures as specified by the Molecular Modeling and Rational Biomaterials Design (MMRBD) project. (2) To formulate and polymerize matrix resin systems containing expandable monomers designed for optimum physicochemical compatibility, reactivity, and expandability; (3) To evaluate and test the physicochemical mechanical, and structural properties of the expandable monomer/epoxy-based matrix resin formulations and (4) To generate bond strength data for Quantitative Structure Activity Relationships so that specific and quantifiable relationships between molecular structure of cationic cure promoters and bonding to tooth structure can be established. This project has four phases of effort corresponding to the four specific aims. The first phase will focus on synthesis and characterization of recommended structures designed and screened using functional group reactivity principles, molecular and computational modeling of reaction energetic nd solubility parameter theory, as suitable monomers for incorporation into cationic matrix resins. The second phase will focus on the formulation and polymerization of matrix resin systems containing these new compounds, and will include studies to determine the effects of water and/or impurities on photocationic cure. The third phase will involve physicochemical characterization and testing of promising matrix resin systems and will include studies to establish polymerizate structure and confirm polymerization pathways of expandable monomer/oxirane comonomer system. The fourth phase will focus on generating data to establish and expand a QSAR data base relating structural features of cationic cure promoters to cure and bonding of cationically cured oxirane based adhesives. Close interaction and sharing between this projects in the program, as guided by the Principal Investigators and coordinated through the Administrative Core, will result in superior, efficacious materials for the next generation of epoxy-based cationic dental adhesive/composite restoratives.

描述(申请人提供)：总体目标是理性地生成 为实现低应力、低收缩而设计的膨胀单体和核心反应物 具有最佳固化特性的高性能树脂体系，结构 完整性和生物兼容性，具有长期临床应用的潜力 作为一种稳定的牙科复合材料粘结剂/基质树脂，我们取得了成功。成功者 这些材料的开发将极大地延长牙齿的寿命 复合/粘合系统，大大改善了牙科病人的护理。在……里面 为了实现这些目标，将实现以下具体目标：(1) 合成最有前景的可膨胀单体和聚合物结构 分子建模与合理生物材料设计(MMRBD) 项目。(2)配制和聚合含有以下成分的基质树脂体系 可膨胀单体专为最佳的物理化学兼容性而设计， 反应性、可扩充性；(3)物化性能评价和测试 可膨胀单体/环氧基复合材料的力学性能和结构性能 基质树脂配方和(4)生成以下粘结强度数据 定量结构活动关系，以便具体和可量化 阳离子固化促进剂的分子结构与结构的关系 可以建立与牙齿结构的结合。该项目分为四个阶段： 与四个具体目标相对应的努力。第一阶段将重点放在 设计和筛选的推荐结构的合成与表征 利用官能团反应原理，分子和计算 适用的反应能和溶解度参数理论的模拟 用于加入阳离子基质树脂的单体。第二阶段将 专注于含有以下成分的基质树脂体系的配方和聚合 这些新化合物，并将包括确定水的影响的研究 和/或光阳离子固化上的杂质。第三阶段将涉及 前景看好的基质树脂体系的物理化学表征与测试 并将包括建立聚合结构的研究和确认 可膨胀单体/环氧乙烷共聚体系的聚合途径。这个 第四阶段将侧重于生成数据，以建立和扩展QSAR数据 将阳离子固化促进剂的结构特征与固化和 阳离子固化环氧烷基胶粘剂的粘接。密切互动和 在校长的指导下，在计划中的此项目之间进行共享 调查人员和通过行政核心进行协调，将导致 优质、高效的下一代环氧基阳离子材料 牙科粘合剂/复合修复剂。