Integrated Matrix Resin/Adhesive Systems

描述（由申请人提供）：总体目标是合理生成 为低应力、低收缩而设计的膨胀单体和共反应物 具有最佳固化特性的高性能树脂体系， 完整性和生物相容性，具有长期临床应用的潜力 成功作为牙科复合材料的稳定粘合剂/基质树脂。成功 这些材料的发展将大大增加牙科的寿命， 复合材料/粘合剂系统，并大大改善牙科患者护理。在 为了实现这些目标，将致力于以下具体目标：（1） 为了合成最有前途的可膨胀单体和聚合物结构， 分子建模和合理生物材料设计（MMRBD） 项目(2)配制和固化基质树脂系统， 为最佳物理化学相容性而设计的可膨胀单体， 反应性、膨胀性;（3）评价和测试 机械和结构性能的可膨胀单体/环氧基 基质树脂配方和（4）为了产生粘结强度数据， 定量结构活动关系，以便具体和可量化 阳离子固化促进剂的分子结构与 可以建立与牙齿结构的结合。该项目分为四个阶段， 与四个具体目标相对应的努力。第一阶段将侧重于 设计和筛选的推荐结构的合成和表征 利用官能团反应性原理，分子和计算 反应能量模型和溶解度参数理论，如适用 用于掺入阳离子基质树脂中的单体。第二阶段将 专注于基质树脂系统的配方和聚合， 这些新化合物，并将包括研究，以确定水的影响， 和/或杂质。第三阶段将涉及 有前途的基质树脂系统的物理化学特性和测试 并将包括研究，以建立聚合物结构和确认 可膨胀单体/环氧乙烷共聚单体体系的聚合途径。的 第四阶段将侧重于生成数据，以建立和扩展QSAR数据 将阳离子固化促进剂的结构特征与固化和 阳离子固化环氧乙烷基粘合剂的粘合。密切互动， 在校长的指导下， 调查人员和通过行政核心协调，将导致 用于下一代环氧基阳离子聚合物的上级有效材料 牙科粘合剂/复合材料清洁剂。

DESCRIPTION (provided by applicant): The overall goal is to generate rationally designed expanding monomers and coreactants for a low stress, low shrinkage high performance resin system with optimal cure characteristics, structural integrity, and biocompatibility that has the potential of long term clinical success as a stable adhesive/matrix resin for dental composites. The successful development of these material would greatly increase the longevity of dental composite/adhesive systems and substantially improve dental patient care. In order to achieve these goals the following specific aims will be addressed: (1) To synthesize the most promising expandable monomer and polymer structures as specified by the Molecular Modeling and Rational Biomaterials Design (MMRBD) project. (2) To formulate and polymerize matrix resin systems containing expandable monomers designed for optimum physicochemical compatibility, reactivity, and expandability; (3) To evaluate and test the physicochemical mechanical, and structural properties of the expandable monomer/epoxy-based matrix resin formulations and (4) To generate bond strength data for Quantitative Structure Activity Relationships so that specific and quantifiable relationships between molecular structure of cationic cure promoters and bonding to tooth structure can be established. This project has four phases of effort corresponding to the four specific aims. The first phase will focus on synthesis and characterization of recommended structures designed and screened using functional group reactivity principles, molecular and computational modeling of reaction energetic nd solubility parameter theory, as suitable monomers for incorporation into cationic matrix resins. The second phase will focus on the formulation and polymerization of matrix resin systems containing these new compounds, and will include studies to determine the effects of water and/or impurities on photocationic cure. The third phase will involve physicochemical characterization and testing of promising matrix resin systems and will include studies to establish polymerizate structure and confirm polymerization pathways of expandable monomer/oxirane comonomer system. The fourth phase will focus on generating data to establish and expand a QSAR data base relating structural features of cationic cure promoters to cure and bonding of cationically cured oxirane based adhesives. Close interaction and sharing between this projects in the program, as guided by the Principal Investigators and coordinated through the Administrative Core, will result in superior, efficacious materials for the next generation of epoxy-based cationic dental adhesive/composite restoratives.