DEVELOPMENT OF COPOLYMER DENTAL ADHESIVE

共聚物牙科粘合剂的研制

• 批准号: 6312731
• 负责人: CECIL C CHAPPELOW
• 金额: $ 14.41万
• 依托单位: UNIVERSITY OF MISSOURI KANSAS CITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-15 至 2001-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6312731
• 关键词: biomaterial compatibility; biomaterial development /preparation; biomaterial evaluation; biomaterial interface interaction; carbonates; chemical structure function; chemical synthesis; copolymer I; cytotoxicity; dental adhesive /sealant; dental bonding material; dentin; free radicals; infrared spectrometry; mutagens; polymerization; polyvinyls; scanning electron microscopy; spirane; tooth enamel; tooth surface

The ultimate objective of this program is the development of a superior dental adhesive that will not only produce a permanent bond to dentin, but to other tooth substrates and restorative materials such as dental composites. The specific aims of this program are: (1) To identify the optimum unsaturated isocyanate/vinyl monomer compositions and determine their reactivity ratios and Q and e values. (2) To control via reactivity ratios the composition of these proposed vinyl copolymers in terms of the content and distribution of desirable functional groups. (3) To determine the adhesive properties of the copolymers to dentin and enamel substrates and evaluate system modifiers that enhance their adhesion. (4) To ascertain the concentration of isocyanate functionality necessary in the copolymer to obtain a maximum adhesive strength to the dental substrate. (5) To ascertain the residual unsaturation, molecular weight, and molecular weight distribution required by the copolymers to provide maximum polymer strength obtainable with final cure. (6) To determine the physical and mechanical properties of the new copolymers developed on this program as potentially superior dental adhesives. (7) To determine and evaluate the microleakage and marginal gap control of these new dental adhesives. (8) To integrate the results of these studies into a fundamental understanding of adhesive molecular design for optimum performance in the oral environment. This subproject will encompass five major phases. Phase 1 will determine monomer reactivity ratios and accomplish aims 1 and 2. Phase 2 is the design and synthesis of copolymer adhesives addressed in specific aims 3, 4, and 5. For Phase 3 the methodology is proposed for the characterization of physicochemical properties and the significance of these properties is addressed in specific aims 4, 5, and 6. Phase 4 is the determination of dental properties and the further enhancement of the adhesive bond strength through system modifiers in specific aim 7. The final phase will address the specific aim 8 and be a critical assessment of the biocompatibility and performance of candidate copolymer dental adhesives, and the development of a protocol for future clinical studies.

该计划的最终目标是发展一个上级 牙科粘合剂，不仅能与牙本质产生永久粘合， 其它牙齿基质和修复材料 复合材料. 该方案的具体目标是： (1)确定最佳不饱和异氰酸酯/乙烯基单体 组成，并确定它们的竞聚率和Q和e值。 (2)为了通过竞聚率控制这些建议的组合物， 乙烯基共聚物在所需的含量和分布方面， 官能团。 (3)为了测定共聚物对牙本质的粘附性能， 搪瓷基材和评价系统的改性剂，提高他们的 粘连 (4)为了确定异氰酸酯官能度的浓度， 共聚物以获得对牙齿的最大粘合强度 衬底 (5)为了确定残余不饱和度、分子量和分子量， 提供最大聚合物所需的共聚物重量分布 最终固化时可获得的强度。 (6)测定新材料的物理力学性能 该计划开发的共聚物具有潜在的上级牙科性能 粘合剂. (7)确定和评价微渗漏和边缘间隙控制 这些新型牙科粘合剂 (8)将这些研究的结果整合到一个基本的 了解粘合剂分子设计，以获得最佳性能， 口腔环境。 这个分项目将包括五个主要阶段。 第一阶段将决定 单体竞聚率，并实现目标1和2。 第二阶段是 共聚物粘合剂的设计和合成在具体目标3中提出， 4和5。 对于第3阶段，提出了表征方法 的物理化学性质和这些性质的意义是 在具体目标4、5和6中处理。 第四阶段是确定 牙科性能和进一步增强的粘合剂粘结强度 通过具体目标7中的系统修改器。 最后阶段将解决 具体目标8，是生物相容性的关键评估， 候选共聚物牙科粘合剂的性能，以及 未来临床研究的方案。