GASTROINTESTINAL HORMONE RESEARCH CENTER CORE

虽然化学信使调节胃肠道的概念 函数已经被认识了很多年，最新的基本进展 研究技术导致了信息的爆炸性增长和对 肠道中的多肽。这些多肽已被证明不仅能发挥作用 对胃肠道的作用千头万绪，也要有深刻的 对人体大多数器官系统的功能产生影响。宽阔的- 肠多肽的扩散分布和作用导致了一个更广泛的基础 跨传统临床学科的研究兴趣和 科学的界限。细胞生物学、生物化学和生物化学的研究进展 分子生物学已经提供了工具，用来研究基因或分子 多肽与临床消化疾病状态之间的联系可能是 已确认身份。然而，由于需求的不同性质， 在临床和基础科学方面，进展相对较小 以统一和广泛的方式处理其中一些问题。 因此，该中心的宗旨是促进 许多弟子的临床和基础科学家的目标是 传播新信息并促进合作研究工作 旨在阐明肠肽在分子水平上的作用 消化疾病的病理生理学。中心，通过它的核心 实验室，提供集体专业知识，使 调查人员扩大他们的研究范围。在上一次 供资期现有的5个核心(放射免疫分析/放射配基、组织 培养、分子生物学、组织化学和生物化学)专注于 关于作为智力资源的主要目标的活动， 房屋专用设备和创新技术，并执行 为中心调查人员提供大量服务。广泛使用这些工具 资源极大地扩大和丰富了调查人员的基础， 在密歇根大学从事胃肠研究。 在当前的申请中，我们建议增加2个核心(细胞生物学和 在体外研究)，以进一步扩展该中心的能力。 通过试点/可行性项目供资机制，调查人员 致力于新的研究领域，培养有才华的年轻人 同伙在他们的实验室里。事实上，在之前的资助期间 在此期间，26个已完成的项目中有25个是正在进行的研究 首创精神。总而言之，中心已成为活动的支点 这激发了庞大而成熟的团队的研究活动 研究人员对密歇根大学现有的肠肽进行了研究。 通过目前的申请，我们正在寻求继续和扩大 中心希望该小组将共同处理 在病理生理学、诊断和治疗中的基本重要性 人类的消化系统疾病。

Although the concept of chemical messengers regulating gastrointestinal function has been recognized for many years, recent advances in basic research techniques has led to an explosion of information and interest in peptides of the gut. These peptides have been shown not only to exert a myriad of actions on the gastrointestinal tract, but also to have profound influences on the function of most of the body's organ systems. The wide- spread distribution and actions of gut peptides has led to a broadened base of investigative interest that crosses traditional clinical disciplines and scientific boundaries. Advances in cell biology, biochemistry, and molecular biology have provided tools with which the genetic or molecular links between peptides and clinical digestive disease states may be identified. However, because of the disparate nature of the demands of clinical and basic science, relatively little progress has been made in approaching some of these questions in a unified and broad-based manner. Thus, it is the purpose of this Center to promote interaction between clinical and basic scientists of many disciples with the aim of disseminating new information and catalyzing collaborative research efforts directed at elucidating the role of gut peptides in molecular pathophysiology of digestive diseases. The Center, through its Core laboratories, provides a collective expertise which has enabled investigators to widen the scope of their research. In the previous funding period the 5 existing Cores (Radioimmunoassay/Radioligand, Tissue Culture, Molecular Biology, Histochemistry, and Biochemistry) focused their activities on the primary goals to serve as an intellectual resource, to house specialized equipment and innovative technology, and to perform numerous services for Center investigators. Extensive use of these resources has greatly expanded and enriched the base of investigators that are involved in gastrointestinal research at the University of Michigan. In the current application we propose 2 additional Cores (Cell Biology and In Vitro Studies) to extend the capabilities of the Center even further. Through the mechanism of pilot/feasibility project funding, investigators have pursued new areas of research as well as developed talented young associates in their laboratories. Indeed, during the previous funding period, 25 of the 26 completed projects have resulted in ongoing research initiatives. In summary, the Center has become the fulcrum of activity that galvanizes the research activities of the large and established group of investigators in gut peptides that exists at the University of Michigan. Through the current application, we are seeking to continue and expand the Center with the hope that together the group will approach questions of fundamental importance in the pathophysiology, diagnosis, and treatment of digestive diseases in man.