GASTROINTESTINAL HORMONE RESEARCH CENTER CORE

虽然化学信使调节胃肠的概念 功能已经认识了很多年，基本的最新进展 研究技术导致了信息和兴趣的爆炸， 肠肽 这些肽已被证明不仅发挥 对胃肠道的作用千头万绪，也要有深刻的 影响身体大部分器官系统的功能。 宽的- 肠肽的广泛分布和作用导致了更广泛的基础 具有跨传统临床学科的研究兴趣， 科学界限。 细胞生物学、生物化学和 分子生物学提供了一种工具， 肽和临床消化系统疾病状态之间的联系可能是 鉴定 然而，由于这些要求的不同性质， 在临床和基础科学方面，进展相对较小， 以统一和基础广泛的方式处理其中一些问题。 因此，本中心的宗旨是促进 临床和基础科学家的许多弟子，目的是 传播新信息和促进合作研究努力 旨在阐明肠肽在分子生物学中的作用， 消化系统疾病的病理生理学 中心通过其核心 实验室，提供了一个集体的专业知识，使 研究人员扩大了他们的研究范围。 上一 现有的5个核心（放射免疫分析/放射性配体、组织 文化，分子生物学，组织化学和生物化学）专注于他们的 关于主要目标的活动，作为智力资源， 拥有专业设备和创新技术， 为中心研究人员提供多种服务。 广泛使用这些 资源大大扩大和丰富了调查人员的基础， 参与了密歇根大学的胃肠道研究。 在本申请中，我们提出了2个额外的核心（细胞生物学和细胞生物学）。 体外研究），以进一步扩展该中心的能力。 通过试点/可行性项目供资机制，调查人员 追求新的研究领域，培养有才华的年轻人， 同事在他们的实验室。 事实上，在过去的融资中， 在此期间，26个已完成的项目中有25个正在进行研究 举措 总之，中心已成为活动的支点 这激发了大型和成熟的小组的研究活动， 密歇根大学的肠肽研究人员。 通过目前的申请，我们正在寻求继续和扩大 中心，希望该小组将共同处理 在病理生理学、诊断和治疗中的重要性 人类的消化系统疾病

Although the concept of chemical messengers regulating gastrointestinal function has been recognized for many years, recent advances in basic research techniques has led to an explosion of information and interest in peptides of the gut. These peptides have been shown not only to exert a myriad of actions on the gastrointestinal tract, but also to have profound influences on the function of most of the body's organ systems. The wide- spread distribution and actions of gut peptides has led to a broadened base of investigative interest that crosses traditional clinical disciplines and scientific boundaries. Advances in cell biology, biochemistry, and molecular biology have provided tools with which the genetic or molecular links between peptides and clinical digestive disease states may be identified. However, because of the disparate nature of the demands of clinical and basic science, relatively little progress has been made in approaching some of these questions in a unified and broad-based manner. Thus, it is the purpose of this Center to promote interaction between clinical and basic scientists of many disciples with the aim of disseminating new information and catalyzing collaborative research efforts directed at elucidating the role of gut peptides in molecular pathophysiology of digestive diseases. The Center, through its Core laboratories, provides a collective expertise which has enabled investigators to widen the scope of their research. In the previous funding period the 5 existing Cores (Radioimmunoassay/Radioligand, Tissue Culture, Molecular Biology, Histochemistry, and Biochemistry) focused their activities on the primary goals to serve as an intellectual resource, to house specialized equipment and innovative technology, and to perform numerous services for Center investigators. Extensive use of these resources has greatly expanded and enriched the base of investigators that are involved in gastrointestinal research at the University of Michigan. In the current application we propose 2 additional Cores (Cell Biology and In Vitro Studies) to extend the capabilities of the Center even further. Through the mechanism of pilot/feasibility project funding, investigators have pursued new areas of research as well as developed talented young associates in their laboratories. Indeed, during the previous funding period, 25 of the 26 completed projects have resulted in ongoing research initiatives. In summary, the Center has become the fulcrum of activity that galvanizes the research activities of the large and established group of investigators in gut peptides that exists at the University of Michigan. Through the current application, we are seeking to continue and expand the Center with the hope that together the group will approach questions of fundamental importance in the pathophysiology, diagnosis, and treatment of digestive diseases in man.