GASTROINTESTINAL HORMONE RESEARCH CENTER CORE

胃肠激素研究中心核心

• 批准号: 2139436
• 负责人: Tadataka Yamada
• 金额: $ 79万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-09-30 至 1995-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2139436
• 关键词: biomedical facility; gastrointestinal hormones; peptide hormone

Although the concept of chemical messengers regulating gastrointestinal function has been recognized for many years, recent advances in basic research techniques has led to an explosion of information and interest in peptides of the gut. These peptides have been shown not only to exert a myriad of actions on the gastrointestinal tract, but also to have profound influences on the function of most of the body's organ systems. The wide- spread distribution and actions of gut peptides has led to a broadened base of investigative interest that crosses traditional clinical disciplines and scientific boundaries. Advances in cell biology, biochemistry, and molecular biology have provided tools with which the genetic or molecular links between peptides and clinical digestive disease states may be identified. However, because of the disparate nature of the demands of clinical and basic science, relatively little progress has been made in approaching some of these questions in a unified and broad-based manner. Thus, it is the purpose of this Center to promote interaction between clinical and basic scientists of many disciples with the aim of disseminating new information and catalyzing collaborative research efforts directed at elucidating the role of gut peptides in molecular pathophysiology of digestive diseases. The Center, through its Core laboratories, provides a collective expertise which has enabled investigators to widen the scope of their research. In the previous funding period the 5 existing Cores (Radioimmunoassay/Radioligand, Tissue Culture, Molecular Biology, Histochemistry, and Biochemistry) focused their activities on the primary goals to serve as an intellectual resource, to house specialized equipment and innovative technology, and to perform numerous services for Center investigators. Extensive use of these resources has greatly expanded and enriched the base of investigators that are involved in gastrointestinal research at the University of Michigan. In the current application we propose 2 additional Cores (Cell Biology and In Vitro Studies) to extend the capabilities of the Center even further. Through the mechanism of pilot/feasibility project funding, investigators have pursued new areas of research as well as developed talented young associates in their laboratories. Indeed, during the previous funding period, 25 of the 26 completed projects have resulted in ongoing research initiatives. In summary, the Center has become the fulcrum of activity that galvanizes the research activities of the large and established group of investigators in gut peptides that exists at the University of Michigan. Through the current application, we are seeking to continue and expand the Center with the hope that together the group will approach questions of fundamental importance in the pathophysiology, diagnosis, and treatment of digestive diseases in man.

尽管调节胃肠道的化学信使的概念 功能已被认可多年，基本的最新进展 研究技术导致了信息和兴趣的爆炸式增长 肠道肽。 这些肽已被证明不仅可以发挥 对胃肠道的作用多种多样，而且还具有深远的影响 影响身体大部分器官系统的功能。 宽幅- 肠肽的扩散分布和作用导致了基础的扩大 具有跨传统临床学科的研究兴趣 科学界限。 细胞生物学、生物化学等领域的进展 分子生物学提供了遗传或分子研究的工具 肽与临床消化疾病状态之间的联系可能是 确定。 但由于需求的性质不同 临床和基础科学方面取得的进展相对较小 以统一和广泛的方式处理其中一些问题。 因此，该中心的目的是促进双方之间的互动。 许多弟子的临床和基础科学家，其目的是 传播新信息并促进合作研究工作 旨在阐明肠肽在分子中的作用 消化系统疾病的病理生理学。 该中心通过其核心 实验室，提供集体专业知识，使 研究人员扩大研究范围。 在之前的 资助期内 5 个现有核心（放射免疫测定/放射配体、组织 文化、分子生物学、组织化学和生物化学）专注于他们的 围绕作为智力资源的主要目标开展的活动 拥有专业设备和创新技术，并执行 为中心调查员提供众多服务。 大量使用这些 资源极大地扩大和丰富了调查人员基础 参与密歇根大学胃肠道研究。 在当前的应用程序中，我们提出了 2 个额外的核心（细胞生物学和 体外研究）进一步扩展该中心的能力。 通过试点/可行性项目资助机制，研究人员 追求新的研究领域并培养有才华的年轻人 实验室里的同事。 事实上，在之前的融资过程中 在此期间，26 个已完成的项目中有 25 个项目正在进行持续研究 倡议。 综上所述，中心已成为活动的支点 激发大型知名团体的研究活动 密歇根大学肠道肽的研究人员。 通过当前的申请，我们正在寻求继续并扩大 中心希望该小组能够共同解决以下问题 在病理生理学、诊断和治疗中具有重要意义 人类消化系统疾病。