U.S.-India Cooperative Research: Organization and Regulation of Organophosphorus Pesticide Degrading Genes in Soil Bacteria

0424002James Wild Description：该奖项授予生物化学领域的联合研究，题为美印合作研究：土壤细菌中有机磷农药降解基因的组织和监管。合作者是德克萨斯农工大学的美国派·詹姆斯·怀尔德和印度阿南塔普尔的SRI Krishnadevaraya大学的达亚南达·西达瓦塔姆教授。研究人员提议从世界几个地区分离出不同菌株的有机磷农药降解细菌(OPD)。本研究将解决OPD基因簇的功能问题，并为研究水平基因转移提供细菌模型系统。这可能会产生关于OPD基因簇、水平基因转移以及这些基因在细菌生长中的作用的非常相关的数据。除了有助于基本了解细菌OPD基因的调控和组织外，这项研究还将对世界各地用于控制主要害虫的杀虫剂的生物修复产生影响。范围：这位美国研究人员已经选择与一位在细菌遗传学、监管和OPD基因多样性方面拥有丰富经验的印度科学家合作。将美国和印度实验室的互补智力资源结合起来，将极大地促进该项目的最终成功。这是一项新的合作，将在两个小组之间建立国际关系，并为青年科学家提供富有成效的培训机会。

0424002James Wild Description: This award is for joint research in biochemistry entitled US-India Cooperative Research: Organization and Regulation of Organophosphorus Pesticide Degrading Genes in Soil Bacteria. The collaborators are US PI James Wild, Texas A&M University and Professor Dayananda Siddavatam of Sri Krishnadevaraya University in Anantapur, India. The researchers propose to isolate different strains of organophosphorus pesticide degrading (opd) bacteria from several regions of the world. This study will address questions about the function of the opd gene cluster and provide a bacterial model system for studying horizontal gene transfer. It could result in very pertinent data on the opd gene cluster, horizontal gene transfer and the role of these genes in the growth of bacteria. In addition to its contribution to fundamental understanding of the regulation and organization of bacterial opd genes, this research will have implications for the bioremediation of pesticides that are used worldwide to control major insect pests. Scope: The US investigator has chosen to collaborate with an Indian scientist that has substantial experience in bacterial genetics, regulation, and diversity of opd genes. Combining the complementary intellectual resources of both US and Indian laboratories will greatly contribute to the eventual success of this project. This is a new collaboration that will create an international relationship between the two groups and provide a fruitful training opportunity for young scientists.