U.S.-India Cooperative Research: Organization and Regulation of Organophosphorus Pesticide Degrading Genes in Soil Bacteria

0424002 James Wild描述：该奖项是为生物化学方面的联合研究，题为“美国-印度合作研究：土壤细菌中有机磷农药降解基因的组织和调控”。 合作者是美国PI詹姆斯野生，得克萨斯州A M大学和教授Dayananda Siddavatam的斯里兰卡Krishnadevaraya大学在阿南塔布尔，印度。 研究人员建议从世界上几个地区分离出不同的有机磷农药降解（opd）细菌菌株。 这项研究将解决有关opd基因簇的功能问题，并为研究水平基因转移提供细菌模型系统。 这将为细菌opd基因簇、水平基因转移以及这些基因在细菌生长中的作用提供非常相关的数据。 除了对细菌opd基因的调控和组织的基本理解做出贡献外，这项研究还将对全世界用于控制主要害虫的农药的生物修复产生影响。 适用范围：美国研究人员选择与一位在细菌遗传学，调控和opd基因多样性方面具有丰富经验的印度科学家合作。 结合美国和印度实验室互补的智力资源将大大有助于该项目的最终成功。 这是一项新的合作，将在两个小组之间建立国际关系，并为年轻科学家提供富有成效的培训机会。

0424002James Wild Description: This award is for joint research in biochemistry entitled US-India Cooperative Research: Organization and Regulation of Organophosphorus Pesticide Degrading Genes in Soil Bacteria. The collaborators are US PI James Wild, Texas A&M University and Professor Dayananda Siddavatam of Sri Krishnadevaraya University in Anantapur, India. The researchers propose to isolate different strains of organophosphorus pesticide degrading (opd) bacteria from several regions of the world. This study will address questions about the function of the opd gene cluster and provide a bacterial model system for studying horizontal gene transfer. It could result in very pertinent data on the opd gene cluster, horizontal gene transfer and the role of these genes in the growth of bacteria. In addition to its contribution to fundamental understanding of the regulation and organization of bacterial opd genes, this research will have implications for the bioremediation of pesticides that are used worldwide to control major insect pests. Scope: The US investigator has chosen to collaborate with an Indian scientist that has substantial experience in bacterial genetics, regulation, and diversity of opd genes. Combining the complementary intellectual resources of both US and Indian laboratories will greatly contribute to the eventual success of this project. This is a new collaboration that will create an international relationship between the two groups and provide a fruitful training opportunity for young scientists.