U.S.-India Cooperative Research: Organization and Regulation of Organophosphorus Pesticide Degrading Genes in Soil Bacteria

描述：该奖项是颁发给生物化学领域的联合研究，题为“美印合作研究：土壤细菌中有机磷农药降解基因的组织和调控”。合作者是美国PI James Wild，德克萨斯农工大学和印度Anantapur的Sri Krishnadevaraya大学的Dayananda Siddavatam教授。研究人员建议从世界几个地区分离出不同的有机磷农药降解（opd）细菌菌株。该研究将解决有关opd基因簇功能的问题，并为研究水平基因转移提供一个细菌模型系统。它可以得到关于opd基因簇、水平基因转移以及这些基因在细菌生长中的作用的非常相关的数据。除了对细菌opd基因的调控和组织的基本理解做出贡献外，这项研究还将对世界范围内用于控制主要害虫的农药的生物修复产生影响。范围：美国研究者选择与一位在细菌遗传学、调控和opd基因多样性方面有丰富经验的印度科学家合作。结合美国和印度实验室的互补智力资源将极大地促进该项目的最终成功。这是一个新的合作，将在两个小组之间建立国际关系，并为年轻科学家提供富有成效的培训机会。

0424002James Wild Description: This award is for joint research in biochemistry entitled US-India Cooperative Research: Organization and Regulation of Organophosphorus Pesticide Degrading Genes in Soil Bacteria. The collaborators are US PI James Wild, Texas A&M University and Professor Dayananda Siddavatam of Sri Krishnadevaraya University in Anantapur, India. The researchers propose to isolate different strains of organophosphorus pesticide degrading (opd) bacteria from several regions of the world. This study will address questions about the function of the opd gene cluster and provide a bacterial model system for studying horizontal gene transfer. It could result in very pertinent data on the opd gene cluster, horizontal gene transfer and the role of these genes in the growth of bacteria. In addition to its contribution to fundamental understanding of the regulation and organization of bacterial opd genes, this research will have implications for the bioremediation of pesticides that are used worldwide to control major insect pests. Scope: The US investigator has chosen to collaborate with an Indian scientist that has substantial experience in bacterial genetics, regulation, and diversity of opd genes. Combining the complementary intellectual resources of both US and Indian laboratories will greatly contribute to the eventual success of this project. This is a new collaboration that will create an international relationship between the two groups and provide a fruitful training opportunity for young scientists.