Expansion of state-of-the-art MR imaging infrastructure for pulmonary disease stratification: POLARIS

扩展用于肺部疾病分层的最先进的 MR 成像基础设施：POLARIS

• 批准号: MR/M008894/1
• 负责人: James Wild
• 金额: $ 954.32万
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FM008894%2F1
• 关键词: Expansion; state; art; MR; imaging

Summary of POLARISThe unique combination of expertise in technology development and the proven ability to translate new technologies into pioneering clinical studies at the University of Sheffield forms the basis of this application for funding. We have long-standing high-level collaborations with both Hospital Trusts in Sheffield (Sheffield Teaching Hospital and Sheffield Children's Hospital) that allow us to apply our developments in all age groups. This has established Sheffield as a national clinical referral centre for image based understanding of lung diseases, but our work has also enabled other centres within the UK to roll out the methods for the benefit of a much wider group of patients. This application is particularly timely with the award of the NIHR Research Professorship to Jim Wild in 2013, which will facilitate the national uptake of the technology at other centres. The expansion of our gas polarisation facilities enabled by this grant will have many benefits for our collaborating centres including creation of a national distribution facility for hyperpolarised gases for those centres that don't have their own polarisation facilities. The ongoing methodological research, clinical evaluations and work with drug companies performed on the planned new state-of-the art 1.5T scanner will ensure that the UK becomes the leading nation in this important area of diagnostic medicine.

POLARIS技术开发专业知识的独特组合以及在谢菲尔德大学将新技术转化为开创性临床研究的成熟能力构成了本申请资金的基础。我们与谢菲尔德的两个医院信托基金（谢菲尔德教学医院和谢菲尔德儿童医院）有着长期的高层合作，这使我们能够将我们的发展应用于所有年龄组。这使谢菲尔德成为一个国家临床转诊中心，用于基于图像的肺部疾病理解，但我们的工作也使英国境内的其他中心能够推出这些方法，使更广泛的患者群体受益。这一申请是特别及时的NIHR研究教授奖吉姆野生在2013年，这将有助于在其他中心的技术的国家吸收。通过这笔赠款，我们的气体极化设施的扩展将为我们的合作中心带来许多好处，包括为那些没有自己的极化设施的中心创建一个超极化气体的国家分配设施。正在进行的方法学研究，临床评估以及与制药公司就计划中的新的最先进的1.5T扫描仪进行的合作将确保英国成为诊断医学这一重要领域的领先国家。

项目成果

Abstract 14282: Electrocardiography Rules out Myocardial Abnormalities on Cardiac Magnetic Resonance Imaging in Post-Hospitalized COVID-19 Patients: A Multicenter Observational Study

摘要 14282：心电图排除住院后 COVID-19 患者心脏磁共振成像的心肌异常：一项多中心观察性研究

• DOI: 10.1161/circ.148.suppl_1.14282
• 发表时间: 2023
• 期刊: Circulation
• 影响因子: 37.8
• 作者: Abd Samat A

A fully automated cardiac magnetic resonance (CMR) assessment improves the evaluation of patients with pulmonary arterial hypertension (PAH)

全自动心脏磁共振 (CMR) 评估可改善肺动脉高压 (PAH) 患者的评估

• DOI: 10.1183/13993003.congress-2021.pa356
• 发表时间: 2021
• 作者: Alabed S

Machine learning cardiac-MRI features predict mortality in newly diagnosed pulmonary arterial hypertension.

• DOI: 10.1093/ehjdh/ztac022
• 发表时间: 2022-06
• 期刊: European heart journal. Digital health

Cardiac-MRI Predicts Clinical Worsening and Mortality in Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis.

心脏-MRI预测肺动脉高压症中的临床恶化和死亡率：系统的综述和荟萃分析。

• DOI: 10.1016/j.jcmg.2020.08.013
• 发表时间: 2021-05
• 期刊: JACC. Cardiovascular imaging
• 作者: Alabed S;Shahin Y;Garg P;Alandejani F;Johns CS;Lewis RA;Condliffe R;Wild JM;Kiely DG;Swift AJ
• 通讯作者: Swift AJ

33 Cardiac MRI thresholds for improvement in pulmonary arterial hypertension

改善肺动脉高压的 33 个心脏 MRI 阈值

• DOI: 10.1136/heartjnl-2022-bscmr.32
• 发表时间: 2023
• 作者: Alabed S