Control of vascular development and signalling by a tissue specific, target selective, alternative splicing regulator

通过组织特异性、靶点选择性、选择性剪接调节器控制血管发育和信号传导

• 批准号: nhmrc : GNT1164734
• 金额: $ 93.3万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/control-vascular-development-splicing-regulator/1379365
• 关键词: Control; vascular; development; signalling; tissue

Our vasculature is important in tissue homeostasis and the pathogenesis of many diseases. Abnormal cell signalling occurs in most known vascular diseases. We have identified a developmental function of a previously under-studied molecular regulator of signalling in vasculature. This project will investigate this factor, building on our recent discoveries with the goal to generate new knowledge that leads to approaches to manipulate vascular signalling in disease in the future.

我们的血管系统在组织稳态和许多疾病的发病机制中起着重要的作用。异常细胞信号传导发生在大多数已知的血管疾病中。我们已经确定了一种以前研究不足的脉管系统信号分子调节剂的发育功能。该项目将研究这一因素，以我们最近的发现为基础，目标是产生新的知识，从而在未来找到操纵疾病血管信号的方法。