Hyperpolarised portable NMR for targeted analytical solutions beyond the laboratory (HYPERSOL)

超极化便携式 NMR，用于实验室以外的目标分析解决方案 (HYPERSOL)

• 批准号: EP/X03528X/1
• 负责人: Meghan Halse
• 金额: $ 219.43万
• 依托单位: University of York
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FX03528X%2F1
• 关键词: Hyperpolarised; portable; NMR; targeted; analytical

In science, access to new data drives innovation. Disruptive technologies transform research by providing quantitativeinformation in a simple and cost-effective way. Consider, for example, the impact of gene sequencing technology onapplications from human health to forensics. Nuclear magnetic resonance (NMR) spectroscopy is a powerful technique thathas revolutionised the physical and biological sciences. However, standard NMR spectrometers are large and expensive,meaning they are confined to dedicated technical facilities. The potential to generate a step change in NMR exists if thedetector could be taken out of the lab and brought to the sample. The challenge is to achieve this without sacrificing thesensitivity and chemical resolving power of laboratory NMR. The unique innovation of the Hyperpolarised NMR Solutionsbeyond the Laboratory (HyperSoL) project is a new method to amplify the NMR response of hydrogen and carbon by factorsof >1000-fold. By accessing chemical information about carbon as well as hydrogen, this method will enhance both thesensitivity and chemical discrimination of portable NMR devices. The HyperSoL project will develop two approaches basedon both commercial and bespoke NMR instrumentation. These methods will maintain instrument portability, while amplifyingsensitivity and chemical resolution for quantifying analytes at natural isotopic abundance. Harnessing this new portable NMRtechnology will liberate NMR from the laboratory, transforming the way that it is used in such disparate areas asmanufacturing, environmental monitoring, forensics and field testing. The fundamental advances that are required tosuccessfully realise this vision can be uniquely delivered by the PI, who has an international track record in advancing NMRdevelopment through fundamental nuclear spin research. This grant would provide the PI with the necessary resources toconsolidate her position as a world-leader in portable NMR technology development.

在科学领域，获取新数据推动创新。颠覆性技术通过以简单和具有成本效益的方式提供定量信息来改变研究。例如，考虑基因测序技术对从人类健康到法医学的应用的影响。核磁共振（NMR）光谱学是一种强大的技术，它彻底改变了物理和生物科学。然而，标准的NMR光谱仪体积大且昂贵，这意味着它们仅限于专用的技术设施。如果探测器可以从实验室中取出并带到样品中，则存在产生NMR阶跃变化的可能性。挑战是在不牺牲实验室核磁共振的灵敏度和化学分辨能力的情况下实现这一目标。超极化NMR解决方案超越实验室（HyperSoL）项目的独特创新是一种将氢和碳的NMR响应放大1000倍以上的新方法。通过获取碳和氢的化学信息，这种方法将提高便携式NMR设备的灵敏度和化学鉴别力。HyperSoL项目将开发两种基于商业和定制NMR仪器的方法。这些方法将保持仪器的便携性，同时提高灵敏度和化学分辨率，用于定量天然同位素丰度的分析物。利用这种新的便携式NMR技术将NMR从实验室中解放出来，改变其在制造、环境监测、取证和现场测试等不同领域的使用方式。成功实现这一愿景所需的基本进展可以由PI独特地提供，PI在通过基础核自旋研究推进NMR发展方面拥有国际记录。这笔赠款将为PI提供必要的资源，以巩固她作为便携式NMR技术开发领域世界领先者的地位。