INSULIN EFFECT ON PROTEIN BIOSYNTHESIS IN DIABETIC CHILDREN

胰岛素对糖尿病儿童蛋白质生物合成的影响

• 批准号: 3742172
• 负责人: KENNETH C COPELAND
• 金额: --
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3742172
• 关键词: age difference; child (0-11); child physical development; drug adverse effect; human subject; human therapy evaluation; insulin; insulin dependent diabetes mellitus; protein biosynthesis; proteolysis

This study tests the hypothesis that anabolic actions of insulin are age-dependent and related to the process of growth. In growing children insulin both stimulates protein synthesis and inhibits proteolysis whereas after growth is completed, insulin has little effect on protein synthesis, but mediates its protein anabolic actions solely via inhibition of proteolysis.

这项研究检验了胰岛素的合成代谢作用是 与年龄相关，并与成长过程有关。在成长中的儿童中 胰岛素既能刺激蛋白质合成又能抑制蛋白质降解 而在生长完成后，胰岛素对蛋白质的影响很小 合成，但仅通过调节其蛋白质合成代谢作用 抑制蛋白质分解。