MOLECULAR GENETICS OF SEXUAL DIMORPHISM

神经结构性别分化的分子基础， 在三种生物体中研究功能。 人类的 遗传在性取向中的可能作用是通过系谱来探讨的 分析、候选基因筛选和分子连锁研究。 一 男性性取向与DNA遗传的相关性 染色体区域Xq 28上的标记已经在一个 有两个同性恋兄弟的家庭的亚群。 该候选基因座与Xq 13处的雄激素受体基因座不同。 在果蝇中，试图克隆无结果基因座，导致雄性- 雄性的求偶行为已经开始了 在大鼠中， 从下丘脑的两性异形区域制备， 筛选性别特异性和雄激素依赖性差异。

The molecular basis for the sexual differentiation of neural structure and function is being investigated in three organisms. In humans, the possible role of heredity in sexual orientation is probed by pedigree analysis, candidate gene screening, and molecular linkage studies. A correlation between male sexual orientation and the inheritance of DNA markers on chromosomal region Xq28 has been detected within a subpopulation of families in which there are two homosexual brothers. This candidate locus is distinct from the androgen receptor locus at Xq13. In Drosophila, attempts to clone the fruitless locus, which leads to male- male courtship behavior, have been initiated. In rat, mRNA has been prepared from a sexually dimorphic region of the hypothalamus and is being screened for sex-specific and androgen-dependent differences.