MOLECULAR GENETICS OF SEXUAL DIMORPHISM

神经结构和性别分化的分子基础 目前正在对三种生物的功能进行研究。在人类中， 遗传在性取向中的可能作用通过系谱进行了探讨 分析、候选基因筛选和分子连锁研究。一个 男性性取向与DNA遗传的相关性 已在染色体区域Xq28上检测到标记 有两个同性恋兄弟的家庭的亚群。 该候选基因座不同于位于Xq13的雄激素受体基因座。 在果蝇中，试图克隆无果的基因座，这会导致雄性- 男性的求爱行为，已经开始了。在大鼠体内，mRNA已经被 从下丘脑性二形区制备而成 筛选出特定性别和雄激素依赖的差异。

The molecular basis for the sexual differentiation of neural structure and function is being investigated in three organisms. In humans, the possible role of heredity in sexual orientation is probed by pedigree analysis, candidate gene screening, and molecular linkage studies. A correlation between male sexual orientation and the inheritance of DNA markers on chromosomal region Xq28 has been detected within a subpopulation of families in which there are two homosexual brothers. This candidate locus is distinct from the androgen receptor locus at Xq13. In Drosophila, attempts to clone the fruitless locus, which leads to male- male courtship behavior, have been initiated. In rat, mRNA has been prepared from a sexually dimorphic region of the hypothalamus and is being screened for sex-specific and androgen-dependent differences.