BIOMEDICAL IMPLICATIONS OF MAGNETIC SUSCEPTIBILITY

本计划项目赠款提案要求继续支持我们的 评估和了解磁化率影响的研究 核磁共振，并使用这些影响来检测和量化生理 功能 高磁化率衬度的动力学效应 试剂用于测量灌注。 内源性铁的改变 化合物用于测量氧消耗。 针对性 超顺磁性氧化铁用于解剖和功能成像。 磁化率的微观变化产生了各种宏观的 后果 建议对这些影响进行协调调查， 为了增强各种器官系统和疾病中的NMR成像， 状态，如癌症和缺血。 研究已经在一个 广泛的调查，包括物理，生物化学和生理 机制等 该计划分为五个研究项目， 通过使用共同的方法和人员， 通过利用共同核心资源： 正常、缺血和肿瘤组织的核磁共振脑研究 基于顺磁性造影剂的瞬时效应和基于固有的 组织中运动的影响; 瞬态磁共振研究心肌灌注 易感性效应和使用氧化铁颗粒的梗塞检测 附着于抗肌球蛋白; 基于NMR图像的氧消耗评估，通过测量 血管内脱氧血红蛋白引起的信号变化; 宏观对比的微观后果分析 磁化率变化; 使用衍生自该化合物的新型造影剂通过NMR进行受体成像 单晶铁氧化物颗粒与各种 生物分子 这五个项目由一个行政核心和三个核心 实验室：核磁共振设施核心;计算和技术核心; 以及高速成像核心

This Program Project Grant proposal requests continued support for our investigations to assess and understand magnetic susceptibility effects in NMR, and to use these effects to detect and quantify physiological function. The dynamic effects of high magnetic susceptibility contrast agents are used to measure perfusion. Alterations in endogenous iron compounds are used to measure oxygen consumption. Targeted superparamagnetic iron oxides are used for anatomic and functional imaging. Microscopic variations in susceptibility generate a variety of macroscopic consequences. A coordinated investigation of these effects is proposed, in order to enhance NMR imaging in a variety of organ systems and in disease states, such as cancer and ischemia. Research has been conducted across a wide range of inquiry, including physical, biochemical and physiological mechanisms. This proposal is divided into five research Projects which interact constructively through the use of shared methodology and personnel and through the utilization of common Core resources: NMR brain studies of normal,ischemic and neoplastic tissues based on transient effects of paramagnetic contrast agents and on intrinsic effects of motion in tissue; NMR studies of myocardial perfusion using transient magnetic susceptibility effects, and infarct detection using iron oxide particles attached to antimyosin; NMR image-based assessment of oxygen consumption by measurement of signal changes resulting from intravascular deoxyhemoglobin; Analysis of the macroscopic contrast consequences of microscopic susceptibility variation; Receptor imaging by NMR using a novel contrast agent derived from the binding of monocrystalline iron oxide particles to a variety of biomolecules. The five projects are supported by an Administrative Core and three Core laboratories: the NMR facilities Core; the Computing and Technologies Core; and the High Speed Imaging Core.