MUTATIONAL MODEL FOR CHILDHOOD CANCER

儿童癌症的突变模型

• 批准号: 2088796
• 负责人: LOUISE C STRONG
• 金额: $ 129.42万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-07-01 至 1998-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2088796
• 关键词: cancer risk; gene mutation; genetic models; neoplasm /cancer genetics; pediatric neoplasm /cancer

We have developed a multidisciplinary program to investigate genetic events leading to childhood cancer using genetic epidemiologic, cellular, and molecular techniques. The hypotheses are based-on a multi-stage model for cancer, and are tested in two model childhood and adolescent cancers, sarcomas and Wilms' tumor of the kidney. For each tumor type, there are specific genes that have been identified that may be altered both as germline mutations and as tumor-specific mutations. There is also significant evidence for genetic heterogeneity in the etiology of each tumor. The underlying themes of the program include characterizing the tumor types with respect to a multi-stage model, determination of the heritable contribution to each tumor, analysis of germline and somatic mutations by type and mechanism, and determination of the implications of germline mutations for the patients and their families. The findings from this program should provide insights into the mechanisms of carcinogenesis as well as guidelines for clinical programs for patients at high risk of cancer.

我们已经开发了一个多学科的项目来研究遗传 使用遗传流行病学，细胞， 和分子技术。 假设是基于一个多阶段模型 并在两种儿童和青少年癌症模型中进行了测试， 肉瘤和肾母细胞瘤。 对于每种肿瘤类型， 已经确定的特定基因可能被改变， 生殖系突变和肿瘤特异性突变。 还有 每种疾病的病因学存在遗传异质性的重要证据， 肿瘤 该计划的基本主题包括表征 对于多阶段模型的肿瘤类型， 每个肿瘤的遗传贡献，生殖系和体细胞分析 突变的类型和机制，并确定的影响， 生殖细胞突变的患者和他们的家庭。 的结果 这个项目应该提供对致癌机制的深入了解 以及高风险患者的临床计划指南， 癌