OPIOIDS AND ORGAN PRESERVATION

阿片类药物和器官保存

• 批准号: 3752868
• 负责人: T P SU
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON DRUG ABUSE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3752868
• 关键词: cryopreservation; endogenous opioid; evaluation /testing; laboratory rat; opioid receptor; tissue /organ preservation

The organ preservation effect of opioids is examined in a single organ preservation preparation. Rat lungs are dissected and preserved in hypothermic solutions with or without a delta opioid peptide DADLE. DADLE markedly enhances the hypothermic preservation time of isolated rat lungs. The functions of the hypothermically preserved lungs with added DADLE are comparable to the functions of the controls which are dissected and studied immediately. Lungs preserved without DADLE functioned poorly in the test.

阿片类药物的器官保存作用在单个器官中进行了研究