OPIOIDS AND ORGAN PRESERVATION

阿片类药物和器官保存

• 批准号: 2449751
• 负责人: T P SU
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON DRUG ABUSE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2449751
• 关键词: endogenous opioid; heart function; heart preservation; heart transplantation; laboratory rabbit; lung; lung transplantation; myocardial ischemia /hypoxia; nonhuman therapy evaluation; perfusion; respiratory function; tissue /organ preservation

This project examines the physiological effects and the underlying biochemical mechanisms of the action of the delta opioid peptides and a related protein factor HIT (Hibernation Induction Trigger) in organ preservation and protection. In a lung transplantation experiment, the lung, after 24 hours of preservation with the HIT, functioned normally when transplanted into the host animal. In another experiment, the delta opioid peptide DADLE was examined for potential myocardial protective action using isolated rabbit hearts. Before subjecting the heart to ischemia, the hearts received a single perfusion of DADLE over a period of 15 minutes. This procedure of DADLE preperfusion dramatically improved recovery of myocardial functions following 18 hours of global ischemia at 4EC when compared to controls. We are currently examining the potential use of DADLE in certain types of CNS damage.

这个项目研究了生理效应和潜在的影响