OPIOIDS AND ORGAN PRESERVATION

阿片类药物和器官保存

• 批准号: 3775041
• 负责人: T P SU
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON DRUG ABUSE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3775041
• 关键词: dogs; endogenous opioid; enkephalins; lung transplantation; opioid receptor; tissue /organ preservation

DADLE and DPDPE, a peptide more selective than DADLE at the delta opioid receptor, markedly prolong the organ survival time in a canine multiorgan preparation. Results of a preliminary transplantation experiment indicate that the recipient dog functions normally after receiving a lung preserved over 40 h with DADLE in the multiorgan preparation.

DADLE和DPDPE，一种在δ阿片样物质上比DADLE更具选择性的肽 受体，显著延长犬多器官存活时间 准备. 初步移植实验的结果 表明受体犬在接受肺后功能正常 在多器官制备中用DADLE保存40 h以上。