BrainHealth - Decoding life course pathways of mental ageing

BrainHealth - 解码心理衰老的生命历程路径

• 批准号: EP/Y015037/1
• 负责人: Esther Walton
• 金额: $ 160.74万
• 依托单位: University of Bath
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FY015037%2F1
• 关键词: BrainHealth; Decoding; life; course; pathways

"The longer I live, the more beautiful life becomes." - Frank Lloyd WrightIn Europe, people aged 65 live approximately 50% of their remaining years with disability. Ageing-related research to date has focused almost exclusively on a deficit-concept of ageing, which seeks to find 'cures' instead of pathways towards healthy senescence. I will break new frontiers with the unconventional approach that ageing starts at birth and requires a life course approach that combines research into early development, adult psychiatry, and mental ageing in old age.The vision of my research program BrainHealth is to fundamentally characterise, improve, and differentiate mental ageing across the lifespan by studying the life course patterns of mental ageing under the innovative umbrella concept of 'brain health'. I will expand and combine unique data from five large European longitudinal cohorts with a total sample size of over 78,000 individuals from birth to old age, creating one of the most comprehensive datasets on brain health worldwide. BrainHealth will include multimodal measures of brain age, epigenetic age, cognitive function, and mental well-being. In an innovative approach, I will develop a novel tissue-specific mouse model that is complimentary to these human data and will help to understand mechanisms, strengthen causal inference and address tissue specificity.Three work packages will be implemented to:1) characterise brain health from birth to old age by establishing robust predictors of brain health in childhood and adolescence;2) improve brain health by identifying modifiable protective factors to enhance brain health across the life course;3) differentiate between physical and mental ageing by developing a tissue-specific mouse model of lifelong brain health.If successful, this program will revolutionise our approach to healthy ageing by permitting the early identification and alteration of unhealthy aging trajectories - a key societal challenge of our time.

“我活得越久，生活就越美好。”-弗兰克·劳埃德·赖特在欧洲，65岁的人大约有50%的剩余寿命是残疾的。迄今为止，与衰老相关的研究几乎完全集中在衰老的缺陷概念上，这种概念试图找到“治疗方法”，而不是健康衰老的途径。我将用非传统的方法打破新的领域，即衰老从出生开始，需要一种生命过程的方法，将研究结合到早期发展，成人精神病学和老年的心理衰老中。我的研究计划BrainHealth的愿景是从根本上改善，改善，并透过研究精神老化的生命历程模式，在以下创新概念下，“大脑健康”。我将扩展并联合收割机从欧洲五个大型纵向队列中获得的独特数据，总样本量超过78，000人，从出生到老年，创建全球最全面的脑健康数据集之一。BrainHealth将包括大脑年龄、表观遗传年龄、认知功能和心理健康的多模式测量。我将以创新的方式开发一种新的组织特异性小鼠模型，该模型将补充这些人类数据，并将有助于理解机制，加强因果推理和解决组织特异性。将实施三个工作包：1）通过建立儿童和青少年时期大脑健康的可靠预测因子，从出生到老年保护大脑健康;2）通过识别可修改的保护因素，改善大脑健康，以促进整个生命过程中的大脑健康; 3）通过开发一种终身大脑健康的组织特异性小鼠模型来区分身体和精神衰老。如果成功，该计划将通过允许早期识别和改变不健康的衰老轨迹来彻底改变我们对健康衰老的方法-我们这个时代的一个关键社会挑战。