SCOR--LUNG BIOLOGY AND DISEASES IN INFANTS AND CHILDREN

SCOR--婴儿和儿童的肺生物学和疾病

• 批准号: 2222968
• 负责人: JOSEPH B WARSHAW
• 金额: $ 73.73万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-12-30 至 1996-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2222968
• 关键词: child (0-11); hyperoxia; lung disorder; newborn animals; perinatal; premature infant human

This proposal is directed toward improving our understanding of factors associated with neonatal lung injury and its long term clinical consequences. The component projects will examine the basis of acute lung injury as well as the sequence of injury that result in long term structural and functional alterations of the airway. The Center will include 6 major projects in addition to defined cores for administrative and programmatic needs of the Center. Specific projects are: 1) Neonatal Lung Matrix Drives Lung Repair. This study will define the influence of oxidant injury on lung epithelial basement membrane matrix interactions; 2) Alveolar Epithelial Differentiation in Oxidant Injury. This study will examine the influence of oxidant injury on Na+/K+ ATPase and gammaglutamyltransferase in lung; 3) Relationship Between Stress Proteins and Antioxidants in Hyperoxia. The heat shock response has been shown to be important in a variety of systems involved in injury and repair. We will examine heat shock proteins in relationship to endogenous antioxidant mechanisms following hyperoxic insult; 4) Regulation of Surfactant Phospholipid Metabolism in Injured Adult and Developing Lungs. This project will examine surfactant phospholipid synthesis in different populations of type II cells following silica induced lung injury; 5) The Influence of Butyrate Acid on SP-A Gene Transcription. This project will study the response of lung to a specific biochemical insult associated with alterations in gene expression; 6) Energetics of Breathing in Infants with Chronic Lung Disease. In this project, we will study alterations in lung work, respiratory efficiency and energy expenditure in infants with BPD who represent the final common pathway of acute lung injury. The SCOR will include 2 Cores which will provide support for the programmatic, educational, and oversight components as well as biostatistical support and a shared instrument facility. A shared morphology and electron microscopy core will provide support for the component laboratory projects. The interactions and shared knowledge provided through the Center will lead to a better understanding of the events underlying lung injury that will be essential before rational strategies for prevention can be rigorously developed and tested.

该提案旨在提高我们对因素的理解 新生儿肺损伤及其长期临床的相关性 结果。 组成项目将检查急性肺病的基础 伤害以及导致长期伤害的顺序 气道结构和功能的改变。 该中心将 除了明确的行政核心之外，还包括 6 个主要项目 和中心的计划需求。 具体项目有： 1）新生儿 肺基质驱动肺修复。 这项研究将确定影响 氧化损伤对肺上皮基底膜基质相互作用的影响； 2） 氧化损伤中的肺泡上皮分化。 这项研究将 检查氧化损伤对 Na+/K+ ATP 酶的影响 肺中的γ谷氨酰转移酶； 3）应激蛋白之间的关系 和高氧中的抗氧化剂。 热休克反应已被证明 在涉及损伤和修复的各种系统中很重要。 我们 将检查热休克蛋白与内源性抗氧化剂的关系 高氧损伤后的机制； 4）表面活性剂的监管 受伤成人和发育中肺部的磷脂代谢。 这 该项目将研究不同条件下表面活性剂磷脂的合成 二氧化硅诱导的肺损伤后的 II 型细胞群； 5) 的 丁酸对 SP-A 基因转录的影响。 该项目将 研究肺部对特定生化损伤的反应 基因表达的改变； 6) 婴儿的呼吸能量 慢性肺部疾病。 在这个项目中，我们将研究肺部的变化 患有 BPD 的婴儿的工作、呼吸效率和能量消耗 代表急性肺损伤的最终共同途径。 SCOR 将 包括 2 个核心，将为程序化、 教育和监督部分以及生物统计支持和 共享仪器设施。 共享形态学和电子显微镜 core将为组件实验室项目提供支持。 这 通过中心提供的互动和共享知识将导致 更好地了解肺损伤的潜在事件 在严格制定合理的预防策略之前至关重要 开发并测试。