DEVELOPMENTAL ADAPTATION

耶鲁大学儿童健康研究中心项目 医学旨在提供密集的基础研究经验 为年轻的儿科教员做好生产和 独立从事生物医学研究和儿科学术研究。这个 这项提案的主题--发展适应，具有独特的相关性 儿科。它涵盖了正常的发育生物学以及 胎儿和儿童对On期间发生的侮辱的适应 创世纪。该项目的多学科性质--借鉴 儿科资深科学家的经验， 生物学、细胞生物学、免疫生物学、遗传学和细胞学 分子生理学--从共同兴趣、频繁演变而来 互动，过去对儿科科学家的培训，以及以下几个领域 教职员工正在进行的合作研究。该计划将继续进行 为儿科青年提供灵活的基础研究体验 科学家通过与中心教职员工的大学互动 中心新项目开发提供的启动资金 并通过该中心的分子生物学核心实验室 新项目开发奖获得者的评选将非常高 具有竞争力，只有那些拥有杰出资历或 潜在的将被计划执行委员会接受。的确有 认识到研究环境的质量最终将 定义该计划的持续成功。该中心的实验室 儿科和基础科学系教员 院系将作为教师研究发展的场所。这个 分子生物学核心实验室将重点研究 分子技术在发育生物学和生物科学中的应用 病理生物学。核心实验室与实验室资源相结合 中心教职员工的能力将补充和扩展 该中心旨在促进新调查员的职业发展。这个 中心的丰富方案，包括定期研究研讨会和 定期的实验室讲习班也将促进年轻人之间的互动 调查人员和中心教职员工。总体而言，中心计划是 通过集中实验室设施和教员， 机构内部研究项目之间的现有互动， 许多核心实验室资源可随时提供给 研究人员，以及已经有高素质申请者的招聘基础 被耶鲁大学临床科室和基础的卓越所吸引 科学。

The Child Health Research Center Program at Yale University School of Medicine is designed to provide intensive basic research experience necessary to prepare young pediatric faculty for productive and independent careers in biomedical research and academic pediatrics. The theme of this proposal, Developmental Adaptation, has unique relevance to pediatrics. It encompasses normal developmental biology as well as the adaptation of the fetus and child to insults occurring during onto genesis. The multidisciplinary nature of the program -- drawing from the experience of established scientists in the Department of Pediatrics, Biology, Cell Biology, Immunobiology , Genetics, and Cellular and Molecular Physiology -- has evolved from the common interests, frequent interactions, past training of pediatric scientists, and several areas of ongoing collaborative research of the faculty. The program will continue to provide flexible basic research experience for young pediatric scientists through collegial interaction with Center faculty through start-up funding as provided by the Center's New Project Development Awards and through the Center's Molecular Biology Core Laboratory The selection of new project development awardees will be highly competitive and only those individuals with exceptional credentials or potential will be accepted by the Program Executive Committee. There is a recognition that the quality of the research environment will ultimately define the continued success of the program. Laboratories of the Center faculty in the Department of Pediatrics and in the basic science departments will serve as sites for faculty research development. The Molecular Biology Core Laboratory will emphasize the application of molecular techniques to the problems of developmental biology and pathobiology. The Core Laboratory combined with the laboratory resources of the Center faculty will complement and extend the capabilities of the Center to foster the career development of new investigators. The enrichment programs of the Center including regular research seminars and periodic laboratory workshops will also promote interactions among young investigators and Center faculty. Overall , the Center program is enhanced by centralization of laboratory facilities and faculty, the existing interactions amongst research programs within the institution, the many Core laboratory resources which are readily available to researchers, and a recruitment base of highly qualified applicants already attracted to the excellence of the Yale clinical departments and basic sciences.