DEVELOPMENTAL ADAPTATION

发育适应

• 批准号: 3103055
• 负责人: JOSEPH B WARSHAW
• 金额: $ 33.23万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-30 至 1995-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3103055
• 关键词: growth /development

The Hallmark of Pediatric science is to recognize and remedy those adverse genetic and environmental influences that can limit the capacity of a child to achieve his/her greatest potential. The goal will require the successfu training of a cadre of pediatrician/scientists who can bring the excitement and technology of modern basic science to improve our understanding of normal developmental events and to those abnormalities of development that continue to result in injury, handicaps and death. The theme of this application, Developmental Adaptation, has unique relevance to Pediatrics. It encompasses normal developmental biology and physiology and the adaptation of the fetus and child to insult occurring during the period of development. The faculty of the program will include a primary faculty in the Department of Pediatrics working closely with an institution-wide resource faculty comprised of pediatrician/scientists, cellular and molecular biologists, neuroscientists, and geneticists who, together with the primary faculty, will guide the young investigators selected for support by this program. The research environment for the four young faculty selected to participate in our Program will be carefully reviewed by the program Advisory Committee with the full recognition that the quality of the environment will ultimately define the success of the program. Laboratories of the Primary and Resource Faculty in the Department of Pediatrics, Yale Center for Molecular Medicine and other departments will serve as the sites for facult research development. The research experience will be enhanced by the educational and programmatic components that will provide an ongoing forum for research interaction of young faculty. We have defined a core laboratory that will support the tissue culture and transgenic mouse needs for a number of investigators whom we have identified as being potential candidates for this program. These specific core facilities combined with the resources of the Primary and Resource Faculty will provide a broad spectrum of scientific investigation to support this program. The Department of Pediatrics provides a large base of training opportunitie including several NIH supported training grants, an NIH funded Children's Clinical Research Center and a highly interactive research oriented faculty A CHRC at Yale will provide an outstanding milieu for interaction, collaboration, and the continued scientific development of young faculty.

儿科科学的标志是认识和补救那些不利的 可能限制儿童能力的遗传和环境影响 发挥他/她最大的潜力。 目标需要成功， 培训一批儿科医生/科学家， 现代基础科学技术，以提高我们的认识， 正常发育事件和那些发育异常， 继续造成伤害、残疾和死亡。 这个应用程序的主题，发展适应，具有独特的 与儿科相关。 它包括正常的发育生物学， 生理学和胎儿和儿童对发生的伤害的适应 在发展时期。 该计划的教师将包括 儿科系的一个主要教员与一个 由儿科医生/科学家组成机构范围的资源教师， 细胞和分子生物学家，神经科学家和遗传学家， 与初级教员一起，将指导年轻的研究人员， 被选中支持这个项目。 四名青年教师被选中参加的研究环境 在我们的计划将仔细审查的计划咨询委员会 充分认识到环境质量将 最终决定项目的成败。 小学实验室 耶鲁大学儿科学系资源学院 分子医学和其他部门将作为学院的地点 研究发展。 研究经验将得到加强， 教育和方案组成部分，将提供一个持续的论坛， 青年教师的研究互动。 我们定义了一个核心 支持组织培养和转基因小鼠需求的实验室 我们已经确定了一些调查员 这个项目的候选人。 这些具体的核心设施， 初级和资源学院的资源将提供广泛的 一系列科学研究来支持这个项目。 儿科提供了大量的培训机会 包括几个NIH支持的培训赠款，一个NIH资助的儿童 临床研究中心和一个高度互动的研究导向的教师 耶鲁大学的CHRC将为互动提供一个出色的环境， 合作，以及年轻教师的持续科学发展。