DEVELOPMENTAL ADAPTATION

发育适应

• 批准号: 2838753
• 负责人: JOSEPH B WARSHAW
• 金额: $ 35万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-30 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2838753
• 关键词: DNA; Xenopus oocyte; biomedical facility; career; child health care personnel; computer assisted sequence analysis; genetically modified animals; growth /development; in situ hybridization; mammalian embryology; molecular biology; molecular cloning; nucleic acid chemical synthesis; oligonucleotides; pediatrics; physicians; polymerase chain reaction; recombinant proteins

The Child Health Research Center Program at Yale University School of Medicine is designed to provide intensive basic research experience necessary to prepare young pediatric faculty for productive and independent careers in biomedical research and academic pediatrics. The theme of this proposal, Developmental Adaptation, has unique relevance to pediatrics. It encompasses normal developmental biology as well as the adaptation of the fetus and child to insults occurring during onto genesis. The multidisciplinary nature of the program -- drawing from the experience of established scientists in the Department of Pediatrics, Biology, Cell Biology, Immunobiology , Genetics, and Cellular and Molecular Physiology -- has evolved from the common interests, frequent interactions, past training of pediatric scientists, and several areas of ongoing collaborative research of the faculty. The program will continue to provide flexible basic research experience for young pediatric scientists through collegial interaction with Center faculty through start-up funding as provided by the Center's New Project Development Awards and through the Center's Molecular Biology Core Laboratory The selection of new project development awardees will be highly competitive and only those individuals with exceptional credentials or potential will be accepted by the Program Executive Committee. There is a recognition that the quality of the research environment will ultimately define the continued success of the program. Laboratories of the Center faculty in the Department of Pediatrics and in the basic science departments will serve as sites for faculty research development. The Molecular Biology Core Laboratory will emphasize the application of molecular techniques to the problems of developmental biology and pathobiology. The Core Laboratory combined with the laboratory resources of the Center faculty will complement and extend the capabilities of the Center to foster the career development of new investigators. The enrichment programs of the Center including regular research seminars and periodic laboratory workshops will also promote interactions among young investigators and Center faculty. Overall , the Center program is enhanced by centralization of laboratory facilities and faculty, the existing interactions amongst research programs within the institution, the many Core laboratory resources which are readily available to researchers, and a recruitment base of highly qualified applicants already attracted to the excellence of the Yale clinical departments and basic sciences.

耶鲁大学儿童健康研究中心项目 医学旨在提供密集的基础研究经验 为年轻的儿科教师做好准备， 在生物医学研究和学术儿科学方面的独立职业。的 该提案的主题是发展适应，具有独特的相关性， 儿科. 它包括正常的发育生物学以及 胎儿和儿童对出生时发生的损伤的适应 创世纪 该方案的多学科性质-借鉴 在儿科部门建立科学家的经验， 生物学，细胞生物学，免疫生物学，遗传学，细胞和 分子生理学--从共同的兴趣、频繁的 互动，儿科科学家的过去培训，以及 学院正在进行的合作研究。 该计划将继续 为年轻儿科医生提供灵活的基础研究经验 科学家通过学院与中心教师的互动， 启动资金由中心的新项目开发提供 奖项和通过该中心的分子生物学核心实验室 新项目开发获奖者的选择将高度 具有竞争力，只有那些具有特殊资质的人， 潜力将被项目执行委员会接受。 有 认识到研究环境的质量将最终 确定该计划的持续成功。 中心实验室 儿科系和基础科学系的教师 各学系将作为教师研究发展的场所。 的 分子生物学核心实验室将重点应用 发展生物学问题的分子技术 病理生物学 核心实验室结合实验室资源 该中心的教师将补充和扩展的能力， 中心，以促进新的调查员的职业发展。 的 该中心的丰富计划，包括定期的研究研讨会， 定期的实验室讲习班也将促进年轻人之间的互动， 研究人员和中心教师。 总的来说，该中心的方案是 通过实验室设施和教师的集中化， 机构内研究项目之间的现有互动， 许多核心实验室资源， 研究人员和高素质的申请人的招聘基地已经 吸引到耶鲁大学临床部门和基础的卓越 以理工科为重