HUC BIOMEDICAL RESEARCH IMPROVEMENT PROGRAM

HUC 生物医学研究改进计划

• 批准号: 2167582
• 负责人: ANTONIO E ALEGRIA
• 金额: $ 42.88万
• 依托单位: UNIVERSITY OF PUERTO RICO AT HUMACAO
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-09-01 至 1998-09-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2167582
• 关键词: minority institution research support

The HUC Biomedical Research Improvement Program has served as the most important source of coordinated efforts between investigators, students and college administration in developing biomedical research at the Humacao University College. The project started with the participation of Chemistry faculty and is expanding to other areas such as Biology and Physics. The purpose of the project is to promote faculty and student participants into the biomedical research mainstream. The program has stimulated the creation and improvement of the administrative and physical infrastructure needed for research. It has also served to provide the needed infrastructure to back up other future projects sponsored by NIH and other agencies. Peer reviewed publications and faculty and student presentations at scientific meetings are and will be possible through the development of this program. Undergraduate science students are involved in biomedical research with the purpose of preparing them for graduate school and stimulate in them the desire to pursue biomedical research careers. This renewal application involves sever (7) biomedical subprojects. Five (5) of these are in the Chemistry, one (1) in the Physiology and another in the Physics area. One of the Chemistry subprojects is intended to explain the mechanism involved in the vascular effects potentiated by vanadium-containing ions. Another chemistry subproject is aimed to determine possible chemical processes that might explain the protective roles of certain fatty acids in certain tumor and cancer initiation processes. A third chemistry subproject will continue to develop new and general methods for the synthesis of amines as applied to the synthesis of drugs with potential neurological activity. A fourth chemistry subproject will deal with the determination of the interrelated roles of internal stability and environment in defining the actual reactivity of semiquinones in electron transfer reactions and lipid peroxidation. A fifth chemistry subproject is aimed to understand the relationship between the structure of phenothiazine derivated, their photochemistry and the phototoxic side-effects exhibited by these drugs. A Physiology subproject will investigate the influence of substance P and acetylcholine in the mucociliary activities of the frog palate 'in vivo' and in outgrowths as a model to understand the role of these substances in humans. A subproject in the area of Biophysics will study the effects of high frequency fields on Magnetic Resonance Imaging quality including the development of a software that corrects the effects of field in homogeneity.

HUC生物医学研究改进计划是迄今为止 研究人员、学生和 和大学管理部门在发展生物医学研究， Humacao大学学院。 该项目始于参与 化学系，并正在扩大到其他领域，如生物学和 物理学 该项目的目的是促进教师和学生 参与者进入生物医学研究主流。 该计划已 鼓励建立和改善行政和 研究所需的基础设施。 它还有助于 提供所需的基础设施，以支持其他未来项目 由NIH和其他机构赞助。 同行评审的出版物和 教师和学生在科学会议上的演讲是，并将是 通过这个项目的发展。 本科理科 学生参与生物医学研究的目的是 为他们准备研究生院，并激发他们的愿望， 从事生物医学研究事业。 本次更新申请涉及七（7）个生物医学子项目。 五 (5)这些是在化学，一（1）在生理学和另一个 在物理领域。 其中一个化学子项目旨在 解释参与血管效应的机制， 含钒离子。 另一个化学子项目旨在 确定可能的化学过程，可以解释保护性 某些脂肪酸在某些肿瘤和癌症发生中的作用 流程. 第三个化学分项目将继续开发新的和 用于合成胺的一般方法 有潜在神经活性的药物 第四种化学反应 次级项目将确定下列方面的相互作用： 内部稳定性和环境在定义实际反应性 电子转移反应和脂质过氧化中的半醌。 一 第五个化学子项目旨在了解 吩噻嗪衍生物的结构、光化学性质 以及这些药物表现出的光毒性副作用。 生理学子项目将研究P物质的影响， 乙酰胆碱在青蛙上颚粘膜纤毛活动中的作用 并在副产物中作为模型来理解这些物质的作用 在人类身上。 生物物理学领域的一个分项目将研究 高频场对磁共振成像质量的影响，包括 开发了一种软件，可以纠正磁场的影响， 同质性