UPRH Biomedical Research Improvement Program

描述（由申请人提供）：我们的SCORE项目的总体目标是升级波多黎各大学胡马考分校（UPRH）的物质和人力资源，以增加和改善其生物医学研究活动。为实现这一主要目标，制定了以下目标：(1)提高协和协和大学的生物医学研究能力；(2)增加协和协和大学从事生物医学研究的自然科学教师数量，以及与研究密集型机构开展生物医学研究合作的数量；(3)增加协和协和大学向校外生物医学研究机构提交的研究资助申请数量；(4)提高协和协和大学的生物医学研究生产力。我们已经开始通过雇用一名全职技术人员来操作和维护我们最复杂的mbrs资助的设备来实现目标(1)。本补充申请通过申请我们的三名新教员生物医学研究者的SCORE项目来回应目标(2)。其中一个研究人员将致力于寻找新的更有效的葡萄糖生物传感器，使用葡萄糖氧化酶（GOx）锚定在用功能化硫醇（通常是两个或三个碳长或苯环）修饰的金表面上，用于检测血液或组织中的葡萄糖。第二个项目将以β -发夹为模型扩展蛋白质途径的β -片折叠知识。本工作收集的信息将有助于对β -发夹折叠驱动力的定性和定量描述。这些结果在最近发展起来的基因组领域具有重要意义，其中蛋白质的结构和功能在医学领域起着至关重要的作用。第三个项目旨在确定在脂质过氧化物偶然降解中形成的活性中间体和产物的身份、分布和命运。从开发的方案中获得的特征加合物将为与组织损伤相关的脂质过氧化结果建模提供有用的信息。预计这些项目的发展将提高向其他校外机构提出更多研究建议申请的可能性，增加研究合作，增加同行评审出版物，同时在国际生物医学研究界对我们的教师和学生的认可。

DESCRIPTION (provided by applicant): The general aim of our SCORE project is the upgrade of physical and human resources at the University of Puerto Rico at Humacao (UPRH) in order to increase and improve its biomedical research activity. The following goals are set in pursuing this major aim: (1) to increase the biomedical research capacity at UPRH, (2) to increase the number of natural sciences faculty at UPRH involved in biomedical research and the number of biomedical research collaborations with research-intensive institutions, (3) to increase the number of submitted research grant applications from UPRH to extramural biomedical research agencies and (4) to increase the biomedical research productivity at UPRH. We have initiated the accomplishment of Goal (1) by hiring a full-time technician for the operation and maintenance of our most sophisticated MBRS-funded equipment. This supplemental application responds to Goal (2) through the application to our SCORE project of three new faculty biomedical investigators. One of these investigators will work to find new and more efficient glucose biosensors, using glucose oxidase (GOx) anchored on gold surfaces modified with functionalized thiols (usually two or three carbons long or benzene ring) which will serve for the detection of glucose in blood or tissues. A second project will expand the knowledge of beta-sheet folding of proteins pathway using beta-hairpin as a model. The information gathered in this work will help in the qualitative and quantitative description of the driving force of beta-hairpin folding. These results are of great importance in the recently developed genome area, where protein structure and function play a crucial role in the medical field. A third project is aimed at determining the identity, distribution, and fate of reactive intermediates and products formed in the fortuitous degradation of lipid peroxides. Characterized adducts derived from the developed protocol will provide information useful in modeling lipid peroxidation outcomes associated with tissue damage. It is expected that the development of these projects will improve the possibilities of producing more research proposal applications to other extramural agencies, more research collaborations and an increase in peer reviewed publications with the concomitant recognition of our faculty and students in the international biomedical research community.