UPRH Biomedical Research Improvement Program

UPRH 生物医学研究改进计划

• 批准号: 6910494
• 负责人: ANTONIO E ALEGRIA
• 金额: $ 35.47万
• 依托单位: UNIVERSITY OF PUERTO RICO AT HUMACAO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6910494
• 关键词: UPRH; Biomedical; Research; Improvement; Program

DESCRIPTION (provided by applicant): The general aim of our SCORE project is the upgrade of physical and human resources at the University of Puerto Rico at Humacao (UPRH) in order to increase and improve its biomedical research activity. The following goals are set in pursuing this major aim: (1) to increase the biomedical research capacity at UPRH, (2) to increase the number of natural sciences faculty at UPRH involved in biomedical research and the number of biomedical research collaborations with research-intensive institutions, (3) to increase the number of submitted research grant applications from UPRH to extramural biomedical research agencies and (4) to increase the biomedical research productivity at UPRH. We have initiated the accomplishment of Goal (1) by hiring a full-time technician for the operation and maintenance of our most sophisticated MBRS-funded equipment. This supplemental application responds to Goal (2) through the application to our SCORE project of three new faculty biomedical investigators. One of these investigators will work to find new and more efficient glucose biosensors, using glucose oxidase (GOx) anchored on gold surfaces modified with functionalized thiols (usually two or three carbons long or benzene ring) which will serve for the detection of glucose in blood or tissues. A second project will expand the knowledge of beta-sheet folding of proteins pathway using beta-hairpin as a model. The information gathered in this work will help in the qualitative and quantitative description of the driving force of beta-hairpin folding. These results are of great importance in the recently developed genome area, where protein structure and function play a crucial role in the medical field. A third project is aimed at determining the identity, distribution, and fate of reactive intermediates and products formed in the fortuitous degradation of lipid peroxides. Characterized adducts derived from the developed protocol will provide information useful in modeling lipid peroxidation outcomes associated with tissue damage. It is expected that the development of these projects will improve the possibilities of producing more research proposal applications to other extramural agencies, more research collaborations and an increase in peer reviewed publications with the concomitant recognition of our faculty and students in the international biomedical research community.

描述(由申请者提供)：我们SCORE项目的总体目标是提升波多黎各大学胡马考分校(UPRH)的物质和人力资源，以增加和改善其生物医学研究活动。在实现这一主要目标时，确定了以下主要目标：(1)提高大学公共卫生学院的生物医学研究能力，(2)增加大学公共卫生学院参与生物医学研究的自然科学教员的数量，以及与研究密集型机构开展生物医学研究合作的数量，(3)增加大学公共卫生学院向校外生物医学研究机构提交的研究资助申请的数量，以及(4)提高大学公共卫生大学的生物医学研究生产力。我们已经开始实现目标(1)，聘请了一名全职技术人员来操作和维护我们最先进的MBR资助设备。此补充应用程序通过三名新的教员生物医学调查人员应用到我们的SCORE项目来响应目标(2)。其中一名研究人员将致力于寻找新的、更有效的葡萄糖生物传感器，使用固定在用官能化硫醇(通常是两到三个碳长或苯环)修饰的金表面的葡萄糖氧化酶(GOx)，这将用于检测血液或组织中的葡萄糖。第二个项目将使用β-发夹作为模型来扩展蛋白质途径的β-折叠的知识。这项工作收集的信息将有助于定性和定量描述β-发夹折叠的驱动力。这些结果在最近发展起来的基因组领域具有重要意义，在该领域，蛋白质的结构和功能在医学领域发挥着关键作用。第三个项目旨在确定在过氧化脂质偶然降解过程中形成的活性中间体和产物的身份、分布和命运。从开发的方案衍生的表征加合物将提供有用的信息，以模拟与组织损伤相关的脂质过氧化结果。预计这些项目的发展将增加向其他校外机构提交更多研究提案申请的可能性，更多的研究合作，以及同行评议出版物的增加，同时我们的教职员工和学生在国际生物医学研究界也会得到认可。