NITRO REDUCTION IN DNA AND PROTEIN TOXICITIES

一种新的氧化还原和其他相关物理性质的研究 硝基芳族化合物的种类，即，苯并唑并[3，2-a]喹啉鎓盐 衍生物（QSD），以了解细胞毒性 这些化合物的机制。由于硝基取代基的存在， 这些化合物和它们对DNA的亲和性，优选的 这些化合物在缺氧条件下对DNA和蛋白质的反应性将是 因为这可能导致一系列新的化合物， 作为低氧特异性细胞毒素或抗肿瘤剂。为此，可能 通过QSD的DNA损伤和蛋白硫醇消耗反应将在 空气的存在和不存在， 剂.将寻求在以下样品中检测到的QSD反应性之间的相关性： 这一工作和缺氧或需氧细胞毒性。这些反应将是 与众所周知的低氧特异性毒性化合物相比。

A study of redox, and other relevant physical properties of a new class of nitroaromatic compounds, i.e., the benzazolo[3,2-a]quinolinium salt derivatives (QSDs), will be performed in order to understand the cytotoxic mechanisms of these compounds. Due to the presence of nitrosubstituents in these compounds and their affinity for DNA, the possibility of a preferred reactivity of these compounds toward DNA and proteins under anoxia will be examined since this could lead to a new series of compounds which could serve as hypoxia-specific cytotoxins or antitumor agents. For this purpose, possible DNA damaging and protein thiol consumption reactions by QSDs will be tested in the absence and presence of air and in the absence and presence reducing agents. Correlations will be sought between the QSDs reactivities detected in this work and anoxic or aerobic cytotoxicities. These reactivities will be compared to those of well known hypoxic-specific toxic compounds.