EVALUATION OF GROWTH HORMONE AND INSULIN-LIKE GROWTH FACTOR IN SHORT STATURE

矮身材生长激素和胰岛素样生长因子的评估

• 批准号: 3765873
• 负责人: SUSAN R ROSE
• 金额: --
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3765873
• 关键词: child (0-11); child physical development; endocrine pharmacology; fetal alcohol syndrome; hormone regulation /control mechanism; hormone therapy; human subject; human therapy evaluation; insulinlike growth factor; postnatal growth disorder; siblings; somatotropin

The mechanisms responsible for persistent slow growth in fetal alcohol syndrome (FAS) are not understood. We hypothesize that the poor growth is a result of identifiable endocrine abnormalities or abnormal tissue response to endocrine factors. FAS children, their normal siblings, and short controls will be evaluated with regard to overnight GH, GH stimulation and IGF-1 generation by exogenous GH. Subsequent in vitro study and treatment protocols will depend on results of this initial work.

胎儿酒精中持续缓慢生长的机制 综合征（FAS）尚不清楚。 我们假设， 是可识别的内分泌异常或异常组织的结果 对内分泌因素的反应。 FAS儿童，他们正常的兄弟姐妹， 将评价短期对照品的过夜GH、GH 刺激和IGF-1产生。 随后的体外 研究和治疗方案将取决于这一初步的结果， 工作