FACTORS REGULATING NOCTURNAL TSH SURGE TEST AS PROBE FOR HYPOTHYROIDISM

夜间 TSH 激增测试作为甲状腺功能减退症探针的调节因素

• 批准号: 6265377
• 负责人: SUSAN R ROSE
• 金额: $ 2.24万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6265377
• 关键词: biomarker; central nervous system; child (0-11); child physical development; chronic disease /disorder; circadian rhythms; clinical research; endocrine disorder diagnosis; hormone biosynthesis; human subject; hypothalamic pituitary axis; hypothyroidism; longitudinal human study; nerve injury; pituitary dwarfism; thyrotropin

An abnormality of the hypothalamic-pituitary-thyroid axis may be present in chronic illness, CNS injury, growth hormone deficiency, and idiopathic short stature. This may be evident in a low nocturnal TSH surge. The TSH surge will be tested in children with these conditions. Patients with a low TSH surge and matched patients with a normal surge will be treated with levothyroxine for 6 months and their growth and clinical responses compared.

慢性疾病、中枢神经系统损伤、生长激素缺乏和特发性身材矮小可能出现下丘脑-垂体-甲状腺轴异常。这可能在夜间低TSH激增中表现得很明显。TSH激增将在患有这些疾病的儿童中进行测试。低TSH激增的患者和匹配的正常激增的患者将接受左旋甲状腺素治疗6个月，并比较他们的生长和临床反应。