CLINICAL TRIAL OF LHRHA IN PUBERTAL PATIENTS WITH SHORT STATURE

LHRHA 在青春期身材矮小患者中的临床试验

• 批准号: 6279750
• 负责人: SUSAN R ROSE
• 金额: $ 2.62万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6279750
• 关键词: adolescence (12-20); body height; child (0-11); clinical research; clinical trials; endocrine disorder chemotherapy; epiphysis; gonadotropin releasing factor; hormone regulation /control mechanism; hormone therapy; human puberty; human subject; human therapy evaluation; peptide hormone analog; postnatal growth disorder

Children with extreme short stature may experience significant stress related to their adult height. Onset of puberty initiates epiphyseal closure and leads to completion of growth. The goal of this study is to treat extremely short pubertal children with a long-acting analog of luteinizing hormone-releasing hormone (D-TRP6-PRO9Net-LHRHa) in order to halt their progression through puberty and delay epiphyseal fusion.

身材极矮的儿童可能会经历巨大的压力 与成人身高有关。 青春期的开始引发骨骺 关闭并导致完成增长。 本研究的目的是 用长效类似物治疗青春期极短的儿童， 促黄体生成激素释放激素（D-TRP 6-PRO 9 Net-LHRHa）， 阻止它们在青春期的发展并延迟骨骺融合。