CLINICAL TRIAL OF LHRHA IN PUBERTAL PATIENTS WITH SHORT STATURE

LHRHA 在青春期身材矮小患者中的临床试验

• 批准号: 6118730
• 负责人: SUSAN R ROSE
• 金额: $ 2.24万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6118730
• 关键词: adolescence (12-20); body height; child (0-11); clinical research; clinical trials; endocrine disorder chemotherapy; epiphysis; gonadotropin releasing factor; hormone regulation /control mechanism; hormone therapy; human puberty; human subject; human therapy evaluation; peptide hormone analog; postnatal growth disorder

Children with extreme short stature may experience significant stress related to their adult height. Onset of puberty initiates epiphyseal closure and leads to completion of growth. The goal of this study is to treat extremely short pubertal children with a long-acting analog of luteinizing hormone-releasing hormone (D-TRP6-PRO9Net-LHRHa) in order to halt their progression through puberty and delay epiphyseal fusion.

极端矮小的儿童可能会经历与其成年身高相关的重大压力。 青春期开始启动骨骺闭合，并导致生长完成。 本研究的目的是用促黄体生成素释放激素（D-TRP 6-PRO 9 Net-LHRHa）的长效类似物治疗青春期极短的儿童，以阻止他们在青春期的进展并延迟骨骺融合。