FREQUENCY OF HEPATITIS C VIRUS-RNA AND HEPATITIS C VIRUS SEROLOGICAL MARKERS

丙型肝炎病毒-RNA 和丙型肝炎病毒血清学标志物的频率

• 批准号: 3770428
• 负责人: S NEDJAR
• 金额: --
• 依托单位: BUREAU OF HEALTH PLANNING AND RESOURCES DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3770428
• 关键词: antiviral antibody; biomarker; enzyme linked immunosorbent assay; hepatitis C virus; human tissue; polymerase chain reaction; serology /serodiagnosis; virus RNA

The presence of antibodies to hepatitis C virus (HCV) is evidence of prior and/or ongoing exposure to HCV infection. Antibody presence, however, might not, in all cases, accurately indicate whether a blood donation contains HCV and is potentially infectious. Levels of HCV-RNA in serum and liver, in general, appear to parallel disease activity, as indicated by increased serum alanine aminotransferase (ALT) levels. In this study, the frequency and overall concordance of appearance of HCV-RNA, using PCR, and antibody, using ELISA and RIBA II, in donor sera will be undertaken.

丙型肝炎病毒（HCV）抗体的存在是先前的证据。 和/或持续暴露于HCV感染。 然而，抗体的存在， 在所有情况下，可能都不能准确地表明献血是否 含有HCV，具有潜在的传染性。 血清HCV-RNA水平和 一般来说，肝脏似乎与疾病活动平行，如 血清丙氨酸氨基转移酶（ALT）水平升高。 本研究 使用PCR检测HCV-RNA的出现频率和总体一致性，以及 抗体，使用ELISA和RIBA II，在供体血清中进行。