RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN NORMAL AND NEOPLASTIC TISSUES

正常和肿瘤组织中的限制性片段长度多态性

• 批准号: 3774332
• 负责人: B ZBAR
• 金额: --
• 依托单位: DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3774332
• 关键词: brain disorders; child (0-11); family genetics; gene deletion mutation; genetic mapping; genetic markers; human genetic material tag; human subject; neoplasm /cancer genetics; pediatric neoplasm /cancer; renal cell carcinoma; restriction fragment length polymorphism; retina disorder; tumor suppressor genes; urinary tract neoplasms

The major goal of the research effort is to define genes involved in the pathogenesis of urologic malignancies. Our major accomplishment this year is the isolation of the von Hippel-Lindau disease (VHL) tumor suppressor gene. The newly isolated gene appears to play a major role in the pathogenesis of sporadic renal cell carcinoma.

研究工作的主要目标是确定参与基因， 泌尿系统恶性肿瘤的发病机制。 我们今年的主要成就 是分离出冯希佩尔-林道病（VHL）肿瘤抑制因子， 基因 新分离的基因似乎在这一过程中起着重要作用。 散发性肾细胞癌的发病机制。