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RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN NORMAL AND NEOPLASTIC TISSUES

RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN NORMAL AND NEOPLASTIC TISSUES
正常和肿瘤组织中的限制性片段长度多态性
批准号：
3808537
负责人：
B ZBAR
金额：
$0.0万
依托单位：
DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3808537
关键词：
cardiovascular neoplasm chromosome walking genetic library genetic mapping genetic markers head /neck neoplasm human genetic material tag human population genetics human subject human tissue linkage mapping molecular cloning neoplasm /cancer genetics nucleic acid probes restriction fragment length polymorphism restriction mapping retina disorder small cell lung cancer squamous cell carcinoma

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英文摘要
The major goal of the research effort was to precisely locate the von Hippel-Lindau disease gene. Previous studies from our laboratory indicated that VHL is located in a 6-8 cM interval between RAF1 and D3Sl8. D3S601 is the closest marker we have identified to the VHL gene; it is located in a region immediately surrounding the VHL gene. We have isolated YAC clones for all markers close to the VHL locus and are in the process of cloning the region by YAC-based chromosome walking. Forty-three probes homozygously deleted in a small cell lung carcinoma line were identified. Human squamous cell carcinomas of the head and neck were shown to be characterized by a loss of alleles at loci on chromosome 3p.
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RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN NORMAL AND NEOPLASTIC TISSUES
RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN NORMAL AND NEOPLASTIC TISSUES
RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN NORMAL AND NEOPLASTIC TISSUES
RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN NORMAL AND NEOPLASTIC HUMAN TISSUES
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