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RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN NORMAL AND NEOPLASTIC HUMAN TISSUES

RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN NORMAL AND NEOPLASTIC HUMAN TISSUES
正常和肿瘤人体组织中的限制性片段长度多态性
批准号：
3916341
负责人：
B ZBAR
金额：
$0.0万
依托单位：
DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3916341
关键词：
biological polymorphism cell transformation cellular oncology gene deletion mutation genetic library genetic mapping human subject kidney neoplasms lung neoplasms molecular cloning oncogenes small cell lung cancer

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中文摘要
翻译
检测到3号染色体短臂上的等位基因丢失 小细胞肺癌与遗传性和非遗传性肾 细胞癌。家族性肾细胞癌的研究 与易患肾脏疾病的基因的概念一致 细胞癌位于染色体3p上。本发明公开了一种用于 人类实体肿瘤中缺失的检测得到了改进。一个 肾细胞癌基因的分离策略是 开发并从3号染色体文库中分离出3000个克隆。
英文摘要
Loss of alleles on the short arm of chromosome 3 was detected in small cell lung carcinoma and hereditary and non hereditary renal cell carcinoma. Studies of familial renal cell carcinoma were consistent with the concept that a gene that predisposes to renal cell carcinoma is located on chromosome 3p. The method for detection of deletions in human solid tumors was improved. A strategy for isolation of the renal cell carcinoma gene was developed and 3000 clones isolated from a chromosome 3 library.
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RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN NORMAL AND NEOPLASTIC TISSUES
RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN NORMAL AND NEOPLASTIC TISSUES
RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN NORMAL AND NEOPLASTIC TISSUES
RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN NORMAL AND NEOPLASTIC TISSUES
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