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RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN NORMAL AND NEOPLASTIC TISSUES

RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN NORMAL AND NEOPLASTIC TISSUES
正常和肿瘤组织中的限制性片段长度多态性
批准号：
3796480
负责人：
B ZBAR
金额：
$0.0万
依托单位：
DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3796480
关键词：
artificial chromosomes brain disorders chromosome walking family genetics gene deletion mutation genetic disorder genetic mapping genetic markers human genetic material tag human subject molecular cloning neoplasm /cancer genetics pulsed field gel electrophoresis restriction fragment length polymorphism restriction mapping retina disorder

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英文摘要
The major goal of the research effort was to precisely locate the von Hippel-Lindau disease gene. Previous studies from our laboratory indicated that VHL is located in a 6-8 cM interval between RAF1 and D3Sl8. D3S601, located between RAF1 and D3SI8, has not shown any recombination with VHL. A long range restriction map around VHL has been prepared by pulsed field gel electrophoresis. The physical map is centered around D3S601. One family has been identified in which affected members appear to have a 200 kb deletion in the VHL gene area. We have isolated YAC clones for all markers close to VHL and are in the process of cloning the region by YAC-based chromosome walking.
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RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN NORMAL AND NEOPLASTIC TISSUES
RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN NORMAL AND NEOPLASTIC TISSUES
RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN NORMAL AND NEOPLASTIC TISSUES
RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN NORMAL AND NEOPLASTIC TISSUES
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