DETECTION OF DRUGS OF ABUSE IN HUMAN SWEAT

人体汗液中滥用药物的检测

• 批准号: 3775040
• 负责人: E J CONE
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON DRUG ABUSE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3775040
• 关键词: blood chemistry; cocaine; drug abuse; drug detection; evaluation /testing; gas chromatography mass spectrometry; hair; immunologic assay /test; marijuana abuse; opiate alkaloid; saliva; sweat; urinalysis

Sweat was evaluated as a media for use in monitoring drug exposure of human subjects. Healthy subjects with a history of chemical substance abuse volunteered for these studies. Informed consent was obtained and all procedures were approved by the hospital Institutional Review Board. Following the administration of cocaine, marijuana or opiates, sweat samples were collected periodically. Other biological specimens like saliva, blood, urine and hair also were collected. Specimens were analyzed by immunoassay and gas chromatography/mass spectrometry. These data will provide new information on this unusual biological specimen which may be useful in development of methods for monitoring human drug exposure.

汗液被评估为用于监测药物暴露的媒介， 人类实验对象 有化学物质史的健康受试者 滥用自愿参加这些研究。 获得知情同意， 所有程序都得到医院机构审查委员会的批准。 服用可卡因、大麻或鸦片制剂后， 定期收集样本。 其他生物标本，如 并收集唾液，血液，尿液及毛发。 标本 通过免疫测定法和气相色谱/质谱法分析。 这些数据将为这种不寻常的生物提供新的信息。 可用于开发监测方法的样本 人类药物暴露