FAST ACTION DYNAMICS OF MARIJUANA

大麻的快速作用动力学

基本信息

  • 批准号:
    2449748
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
  • 资助国家:
    美国
  • 起止时间:
  • 项目状态:
    未结题

项目摘要

Despite widespread use of urine cannabinoid assays in drug treatment, workplace monitoring, and forensic toxicology programs, limited urinary cannabinoid excretion data are available in the literature to aid in the interpretation of test results. Much of the available published information is based on the use of non-specific immunoassay tests that have dramatically changed performance characteristics over time. Also, both the timeframe of specimen collection and the number of specimens analyzed in these studies have been restricted. The urinary excretion kinetics of smoked marijuana have been characterized utilizing GC/MS urine cannabinoid data collected in this study. Substantial intersubject variability was noted between subjects and between doses in patterns of 11-nor-9-carboxy-D9-tetrahydrocannabinol (THCCOOH) excretion. Mean peak urine THCCOOH concentrations averaged 89.8 +/- 31.9 ng/mL and 153.4 +/- 49.2 ng/mL following smoking of approximately 15.8 mg and 33.8 mg THC, respectively. The mean times of peak urine concentration were 7.7 h +/- 0.8 after the 1.75% THC and 13.9 h +/- 3.5 after the 3.55% THC dose. Mean GC/MS THCCOOH detection times for the last positive urine sample following the smoking of a single 1.75% or 3.55% THC cigarette were 33.7 +/- 9.2 h and 88.6 +/- 9.5 h, respectively, when a 15 ng/mL cutoff concentration was utilized. Although it is known that the excretion of marijuana metabolites occurs over an extended period of time, few studies have been designed to accurately estimate excretion half-lives. We monitored excretion of the primary urinary metabolite of marijuana, THCCOOH, by GC/MS. Terminal elimination half-lives of THCCOOH were determined in six male subjects following smoking of a single 1.75% or 3.55% THC cigarette by both the amount remaining to be excreted (ARE) or sigma minus method and by the excretion rate method. Mean +/- SEM half-lives calculated by the ARE method following the low or high dose were 31.4 +/- 1.1 h (range 27.8 to 35.3) and 28.6 +/- 1.5 h (range 24.9 to 34.5), respectively. The amounts of THCCOOH excreted over a seven day period were 93.9 +/- 24.5 ug (range 34.6 to 171.6) and 197.6 +/- 33.7 ug. This study documents the prolonged excretion of THCCOOH in urine and emphasizes the importance of study design in precise estimation of terminal elimination half-lives. A sensitive analytical method and a one to two week specimen collection period are important study considerations in the monitoring of marijuana excretion.
尽管在药物治疗中广泛使用尿大麻素测定, 工作场所监测和法医毒理学计划,有限的尿 大麻素排泄数据可在文献中获得,以帮助 测试结果的解释。 大部分可用的出版物 信息是基于使用非特异性免疫测定试验, 随着时间的推移,性能特征发生了巨大变化。 还有, 样本采集的时间和样本数量 在这些研究中分析的数据受到限制。 尿液排泄 已经利用GC/MS表征了吸食大麻的动力学 在这项研究中收集的尿大麻素数据。实质性间题 在受试者之间和剂量之间观察到变异性, 11-去甲-9-羧基-D9-四氢大麻酚(THCCOOH)排泄。 平均峰 尿THCCOOH浓度平均为89.8 +/- 31.9 ng/mL和153.4 +/- 49.2 ng/mL,吸烟后约为15.8 mg和33.8 mg THC, 分别 平均尿峰时间为7.7h ± 1 0.8在1.75%THC剂量后13.9 h +/-3.5 h和3.55%THC剂量后13.9 h +/-3.5 h。是说 最后一份阳性尿样的GC/MS THCCOOH检测时间 吸1.75%或3.55%THC香烟后, 当临界值为15 ng/mL时,分别为+/- 9.2 h和88.6 +/- 9.5 h 使用浓度。 尽管已知大麻代谢物的排泄发生在 在很长一段时间内,很少有研究被设计为 准确估计排泄半衰期。我们监测了 大麻的主要尿代谢产物THCCOOH(GC/MS)。 在6名男性受试者中测定THCCOOH的消除半衰期 在吸了一支1.75%或3.55% THC的香烟后, 剩余排泄量(ARE)或sigma-法, 排泄率法通过ARE计算的平均+/- SEM半衰期 低剂量或高剂量后的方法为31.4 +/- 1.1小时(范围27.8至 35.3)和28.6 +/- 1.5 h(范围24.9 - 34.5)。 的量 在7天内排泄的THCCOOH为93.9 +/- 24.5 μ g(范围 34.6至171.6)和197.6 +/- 33.7微克。这项研究记录了 THCCOOH在尿液中的排泄,并强调研究的重要性 精确估计终末消除半衰期的设计。 一 灵敏的分析方法和一到两周的样本收集 在大麻的监测中, 排泄

项目成果

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E J CONE其他文献

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{{ truncateString('E J CONE', 18)}}的其他基金

DETECTION OF DRUGS OF ABUSE IN ALTERNATIVE BIOLOGICAL FLUID AND TISSUES
替代生物体液和组织中滥用药物的检测
  • 批准号:
    6161686
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
FAST ACTION DYNAMICS OF MARIJUANA
大麻的快速作用动力学
  • 批准号:
    3752836
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
PHARMACOKINETICS AND PHARMACODYNAMICS OF DRUGS OF ABUSE IN HAIR
头发中滥用药物的药代动力学和药效动力学
  • 批准号:
    3775070
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
PHARMACOKINETICS AND PHARMACODYNAMICS OF DRUGS OF ABUSE IN HAIR
头发中滥用药物的药代动力学和药效动力学
  • 批准号:
    3838652
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
PHARMACOKINETICS AND PHARMACODYNAMICS OF OPIATE ANALGESICS
阿片类镇痛药的药代动力学和药效学
  • 批准号:
    3838646
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
VALIDITY STUDIES OF COMMERCIAL DRUG SCREENING ASSAYS
商业药物筛选试验的有效性研究
  • 批准号:
    3838558
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
DETECTION OF DRUGS OF ABUSE IN HUMAN SALIVA
人类唾液中滥用药物的检测
  • 批准号:
    3853671
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
VALIDITY STUTIES OF COMMERCIAL DRUG SCREENING ASSAYS
商业药物筛选试验的有效性研究
  • 批准号:
    2449746
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
DETECTION OF DRUGS OF ABUSE IN HUMAN SALIVA
人类唾液中滥用药物的检测
  • 批准号:
    3752830
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
ASSESSMENT OF THE RISK OF PASSIVE INHALTION OF DRUGS
被动吸入药物的风险评估
  • 批准号:
    6161720
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:

相似海外基金

Cannabinoids, Inflammation/Infection and Microglia: Relation to Brain and Behaviour
大麻素、炎症/感染和小胶质细胞:与大脑和行为的关系
  • 批准号:
    502602
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
Peripherally-restricted non-addictive cannabinoids for cancer pain treatment
用于癌症疼痛治疗的外周限制性非成瘾大麻素
  • 批准号:
    10726405
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
Indiana University Bloomington (IUB) Center for Cannabis, Cannabinoids, and Addiction (C3A)
印第安纳大学伯明顿分校 (IUB) 大麻、大麻素和成瘾中心 (C3A)
  • 批准号:
    10713089
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
Defining the impact of cannabinoids on the HIV reservoir in humanized mice
确定大麻素对人源化小鼠 HIV 储存库的影响
  • 批准号:
    10814024
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
Computation-assisted discovery of bioactive minor cannabinoids from hemp
计算辅助从大麻中发现生物活性次要大麻素
  • 批准号:
    10791213
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
A triple-blind, placebo-controlled, randomized clinical trial of CANnabinoids for Drug Resistant Epilepsy (CAN-DRE) in adults and children
大麻素治疗成人和儿童耐药性癫痫 (CAN-DRE) 的三盲、安慰剂对照、随机临床试验
  • 批准号:
    479757
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Operating Grants
Elusidation for Toxicity Mechanism of Synthetic Cannabinoids by Multi-omics Approach: Focusing on Cardiovascular System
多组学方法阐明合成大麻素的毒性机制:聚焦心血管系统
  • 批准号:
    23K09762
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Inhibition of visceral sensation by cannabinoids in the gastrointestinal tract
大麻素在胃肠道中抑制内脏感觉
  • 批准号:
    RGPIN-2021-03491
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
    Discovery Grants Program - Individual
On-demand continuous flow manufacturing of cannabidiol (CBD) and other cannabinoids
大麻二酚 (CBD) 和其他大麻素的按需连续流制造
  • 批准号:
    570513-2021
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
    Alliance Grants
The Acute Effects of Cannabis and Cannabinoids on Human Cardiovascular Physiology: Understanding Contributing Mechanisms in the Myocardium, Peripheral Vasculature, and Autonomic Nervous System.
大麻和大麻素对人类心血管生理学的急性影响:了解心肌、外周脉管系统和自主神经系统的贡献机制。
  • 批准号:
    548126-2020
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
    Alexander Graham Bell Canada Graduate Scholarships - Doctoral
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