ASSESSMENT OF THE RISK OF PASSIVE INHALTION OF DRUGS

被动吸入药物的风险评估

• 批准号: 6161720
• 负责人: E J CONE
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON DRUG ABUSE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6161720
• 关键词: air sampling /monitoring; behavioral /social science research tag; blood chemistry; clinical research; cocaine; disease /disorder proneness /risk; drug metabolism; excretion; gas chromatography mass spectrometry; gastrointestinal drug absorption; human subject; inhalation drug abuse; intravenous drug abuse; male; passive smoking; urinalysis; vapor

When drugs of abuse are smoked, volatile components and pyrolysis material escape into the atmosphere. Depending on the local environment, bystanders may be exposed to the drug by passive inhalation of the contaminated air. Artificial methods have been developed to smoke drugs of abuse in a controlled environment and to measure drug concentrations in air. These methods were then applied to the design of human clinical studies to assess the hazards of environmental exposure to drugs. Subjects were exposed to vaporized drug in a small unventilated room. The study was performed under blind conditions with placebo control and multiple active doses of drug. Urine, blood and saliva samples were collected and analyzed by immunoassay and by solid-phase-extraction followed by analysis by gas chromatography-mass spectrometry. Results indicated that subjects level of drug exposure are dependent upon numerous factors including the amount of drug in air, length of exposure, and degree of room ventilation. It was clear that unknowing drug exposure could be dangerous to unsuspecting bystanders, particularly to small children. These studies will establish limits of exposure to volatile components of drugs under controlled conditions.

当吸食滥用药物时，挥发性成分和热解 物质逃逸到大气中。取决于当地的 环境中，旁观者可能被动地接触到药物 吸入被污染的空气。人工方法已经被 发展成在受控环境中吸食滥用药物并 测量空气中的药物浓度。这些方法随后被应用于 用于人类临床研究的设计，以评估 在环境中暴露于毒品。受试者暴露在雾化的环境中 毒品放在一个不通风的小房间里。这项研究是在盲目情况下进行的 有安慰剂对照和多次有效剂量药物的情况。 尿液、血液和唾液样本采集并分析 免疫分析和固相萃取-气相分析 色质联用。结果表明，受试者 接触毒品的程度取决于许多因素，包括 空气中药物的量、暴露的时间和房间的程度 通风。显然，在不知情的情况下接触毒品可能会 对毫无戒心的旁观者，特别是对小孩子来说是危险的。 这些研究将确定接触挥发性成分的限度。 在受控条件下的药物。