PHARMACOKINETICS AND PHARMACODYNAMICS OF DRUGS OF ABUSE IN HAIR

头发中滥用药物的药代动力学和药效动力学

• 批准号: 3838652
• 负责人: E J CONE
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON DRUG ABUSE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3838652
• 关键词: biomarker; blood chemistry; case history; drug abuse; drug detection; gas chromatography mass spectrometry; hair; human subject; male; pharmacokinetics; radioimmunoassay; saliva; urinalysis

Drug residues have been detected in human hair specimens by a variety of analytical techniques. These reports have generated substantial interest in using hair as a historical record of drug usage. Studies are designed to determine the presence and time course of drugs of abuse in human hair. Healthy male volunteers with a history of chemical substance abuse will participate in the study. Informed consent will be obtained and all procedures will be approved by the hospital Institutional Review Board. Subjects will reside on the clinical ward of the ARC. Head and facial hair specimens will be obtained prior to and after administration of drugs of abuse. Blood, saliva and urine specimens also will be obtained. Analyses of tissue and biofluids for drug will be performed by radioimmunoassay and gas chromatography/mass spectrometry. The studies will provide the scientific basis for determination of the usefulness of hair as a "historical record" for substance abuse.

通过多种方法在人发标本中检测到药物残留 分析技术。 这些报告引起了极大的兴趣 用头发作为药物使用的历史记录 研究设计 确定人类滥用药物的存在和时间过程 头发 有化学物质滥用史的健康男性志愿者将 参与这项研究。 将获得知情同意书， 这些程序将由医院机构审查委员会批准。 受试者将居住在ARC的临床病房。 头部和面部 将在给药前和给药后采集毛发样本， 滥用药物。 还将采集血液、唾液和尿液样本。 药物的组织和生物体液分析将由 放射免疫分析和气相色谱/质谱法。 这些研究将为确定 头发作为药物滥用的“历史记录”的有用性。