MECHANISMS OF CHEMICALLY INDUCED PHOTOSENSITIVITY

已知光与内源或外源化学物质相互作用 在皮肤或眼睛中，产生光敏作用。这种现象可能 有害的(光毒性或光过敏)或可能有用 治疗学(牛皮癣或肿瘤的光动力治疗)。这个 这个项目的目标是确定光所扮演的角色- 光敏化过程中诱导的自由基物种。此外，努力 旨在鉴定光敏剂，可能是 在治疗上更有效。1，5-二氨基-4，8-二甲氧基-蒽醌 和相关类似物都是O2和1O2的有效生成器 可见光照明。这些化合物对K562有活性。 培养中的人慢性髓系白血病细胞导致直链 DNA断裂。也是潜在的光动力学物质 试剂，在可见光照射下会变成强氧化剂。 抗菌抗菌剂N-羟基-2-硫代吡啶的紫外光辐照 真菌制剂，产生羟基自由基和相应的N- 羟基-2-吡啶硫基自由基。

Light is known to interact with endogenous or exogenous chemical agents in the skin or eyes, to produce photosensitization. This phenomenon may be deleterious (phototoxicity or photoallergy) or may be useful therapeutically (photodynamic treatment of psoriasis or tumors). The objective of this project is to determine the role played by light- induced free radical species in photosensitization. In addition, efforts are directed towards the identification of photosensitizers that may be more efficient therapeutically. 1,5-Diamino-4,8-dimethoxy-anthraquinone and related analogs were efficient generators of both O2 and 1O2 upon visible light illumination. These compounds were active against K562 human chronic myeloid leukemic cells in culture causing frank strand breaks in DNA. Anthrapyrazoles, which are also potential photodynamic agents, become strong oxidizers upon illumination with visible light. UV-irradiation of N-hydroxy-2-thiopyridine, an anti-bacterial and anti- fungal agent, generated the hydroxyl radical and the corresponding N- hydroxy-2-pyridine thiyl radical.