MOUSE MUTANT GENE RESOURCE

小鼠突变基因资源

• 批准号: 3103380
• 负责人: MURIEL T DAVISSON
• 金额: $ 46.74万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-07-01 至 1998-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3103380
• 关键词: animal breeding; animal colony; gene mutation; genetic models; laboratory mouse

The long range goal of the Mouse Mutant Gene Resource (MMGR) at The Jackson Laboratory is to provide a continuing source of new spontaneous mutations for biological and biomedical research. Spontaneous mutations in the mouse are the primary source of models for human conditions for which the mutated gene has not been cloned. The specific objectives of the MMGR program are to (1) identify new mutations in the mouse; (2) characterize the new mutants genetically, phenotypically, and pathologically; (3) establish the new mutations in strains suitable for further analysis by us and others; (4) preserve them as frozen embryos to assure their continued availability, and (5) provide mutants and controls to other investigators. The new mutations will be identified from among phenotypic deviants appearing in The Jackson Laboratory's breeding colonies. They will be characterized genetically by determining the mode of inheritance, testing for allelism with any already known mutations that produce similar phenotypes, and determining the chromosomal location. The new mutants will be characterized pheonotypically by observing their fertility, growth, viability, life span, and behavior and by defining their anatomical, histopathological, and physiological abnormalities. New mutants with potential for biomedical research will be maintained, preserved as frozen embryos, described in the open literature, and made available to other investigators at The Jackson Laboratory and in the world-wide scientific community.

小鼠突变基因资源(MMGR)的长期目标 杰克逊实验室将继续提供新的自发来源 用于生物和生物医学研究的突变。自发突变 是人类条件模型的主要来源 突变的基因还没有被克隆。的具体目标 MMGR计划是为了(1)识别小鼠的新突变；(2) 对新的突变体进行基因、表型和 在病理学上；(3)建立适合于 我们和其他人的进一步分析；(4)将它们作为冷冻胚胎保存 以确保它们的持续供应，以及(5)提供突变体和 把控制权交给其他调查人员。新的突变将被识别出来 从杰克逊实验室中出现的表型异常中 繁育的殖民地。他们将通过确定基因特征来确定 遗传模式，测试与任何已知的 产生相似表型的突变，并决定 染色体定位。新的突变体将被描述为 通过观察它们的生育力、生长发育、生存能力、生命 跨度和行为，并通过定义它们的解剖学、组织病理学 和生理异常。新的突变体具有潜在的 生物医学研究将被维持，作为冷冻胚胎保存， 在开放文献中描述，并向其他人提供 杰克逊实验室和世界范围内的科学研究人员 社区。