Crossing a frontier in cardiac fibrosis: a single-cell multi-omics approach to understanding fibroblast agency in models of heart disease

心血管疾病是社会上最严重的死亡和发病原因，每13分钟就有一名澳大利亚人死亡。我们的重点是心脏成纤维细胞--调节心脏机械完整性的可变细胞，是心脏病的关键治疗靶点。单细胞方法使复杂组织的研究发生了革命性的变化。在这里，我们将对数以千计的单个心脏细胞进行分子分析，以建立一个新的抗击心脏病的概念框架。

Cardiovascular disease is the most serious cause of mortality and morbidity in society, with one Australian dying every 13 mins. Our focus is on cardiac fibroblasts - changeable cells that regulate the mechanical integrity of the heart, and which are key therapeutic targets in heart disease. Single cell methods have revolutionised the study of complex tissues. Here we will apply molecular assays to thousands of single heart cells to build a new conceptual framework for fighting heart disease.