RESEARCH CENTER FOR CEREBRAL VASCULAR DISEASE

脑血管疾病研究中心

• 批准号: 3099248
• 负责人: MYRON DAVID GINSBERG
• 金额: $ 100.42万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-08-01 至 1995-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3099248
• 关键词: bioenergetics; brain circulation; brain injury; brain metabolism; cerebral ischemia /hypoxia

The objective of our research program is to conduct an integrated multidisciplinary inquiry into the mechanisms and treatment of ischemic brain injury. Our investigations, grounded in experimental animal models of cerebral ischemia, have as their ultimate goal the identification of those factors responsible for ischemic injury which may be amenable to therapeutic or prophylactic intervention. The Program Project consists of six investigative proposal together with Core facilities supporting the research program in the areas of brain metabolite analysis, animal physiology, radioisotopic tracer strategies, morphology, computer science/image-processing, and animal behavior. The Cores contribute substantively to the implementation of each Project and unify the Projects by common methodological approaches. Program areas include: (1) treatable mechanisms of brain injury in foal cerebral ischemia; (2) mechanisms of functional recovery following cerebral infarction; (3) an analysis of glutamatergic mediation of ischemic vulnerability; (4) the effect of mild selective cerebral hypothermia in protecting against ischemic brain injury; (5) studies of early indices of cellular damage in the hippocampal slice preparation; and (6) an analysis of local cortical electrophysiological and ion-transport alterations in acute focal cerebral ischemia and their relationship to ultimate tissue injury.

我们研究计划的目标是进行一项综合的 脑缺血发病机制及治疗的多学科探讨 脑部受伤。我们的研究以实验动物模型为基础 作为他们的最终目标是确定脑缺血的 那些导致缺血性损伤的因素，可能是 治疗性或预防性干预。该计划项目包括 六项调查建议及核心设施支援 大脑代谢物分析、动物领域的研究计划 生理学、放射性同位素示踪策略、形态学、计算机 科学/图像处理和动物行为。这些核心有助于 切实抓好每个项目的实施，统一 这些项目采用共同的方法方法。计划领域包括： (1)胎脑缺血脑损伤的治疗机制；(2) 脑梗塞后功能恢复的机制；(3)ANP 谷氨酸能介导的缺血易损性分析；(4) 浅选择性脑低温对脑缺血再灌注损伤的保护作用 缺血性脑损伤；(5)早期细胞损伤指标的研究 海马区脑片制备；(6)局部皮质分析 急性局灶性脑损伤的电生理和离子转运改变 脑缺血及其与终极组织损伤的关系。